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Laura’s work focuses on how bacteria develop resistance to antibiotics. This is a growing problem, as more strains of bacteria become resistant to the drugs that were primarily developed more than 20 years ago. Her research focuses on how antibiotic resistance arises, and defining and characterising mechanisms of resistance that have a clinical relevance.
She is also exploring the role of antibiotic resistance mechanisms in the ability of the organism to colonise, survive and cause infection in their host. Laura is particularly interested in the systems that allow transport of antibiotics into and out of bacteria. Adaptations to these systems occur in bacteria and cause multiple drug resistance. Although this work has many applications, Laura has made particularly detailed studies of food borne bacteria such as Salmonella and Campylobacter, and the pneumococcus that causes pneumonia.
Current work is in three areas (1) mechanisms of regulation of expression of Gram bacterial efflux pumps and how this impacts upon the ability of the bacterium to infect the host, (2) identifying inhibitors of efflux, and (3) inhibition of transfer of plasmids (mobile genetic elements) between bacteria.
Laura receives support for her research from the MRC and BBSRC and she has a Roche 'Extending the Innovation Network' Award. Since 1985 Laura has successfully supervised 30 PhD projects. Her team currently comprises 4 post-doctoral research fellows, 2 technicians, and 1 postgraduate student.
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Alistair D. Middlemiss,James R. J. Haycocks,Anne M. Stringer,Laura J. V. Piddock,Joseph T. Wade,David C. Grainger
MICROBIOLOGY-SGMno. 5 (2023)
Antimicrobial agents and chemotherapyno. 11 (2023): e0062023-e0062023
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Alasdair P MacGowan, M L G Attwood,Alan R Noel, R Barber,Zachary Aron,Timothy J Opperman,Elizabeth Grimsey,Jack Stone,Vito Ricci,L J V Piddock
The Journal of antimicrobial chemotherapyno. 12 (2023): 2869-2877
Alistair D Middlemiss,James R J Haycocks,Anne M Stringer,Laura J V Piddock,Joseph T Wade,David C Grainger
Microbiology (Reading, England)no. 5 (2023)
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2023)
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