Research summary
Our research focuses on a class of proteins with very distinctive architectures, known as tandem-repeat proteins. Our group and others have shown that the simple modular, one-dimensional architecture of tandem-repeat proteins gives them distinctive properties that make it uniquely straightforward to map the energetics of their structures and to rationally redesign their stability, folding and binding function.

This class of proteins is thus an exceptionally sensitive and versatile tool that we are now exploiting to dissect otherwise intractable cellular mechanisms. We are also exploring how to exploit the extraordinary design-ability of these proteins for biomedical and biotechnology applications.