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Dr. Kresty’s research is focused on characterizing molecular and biologic alterations leading to esophageal and lung cancers with the goal of developing efficacious interventions for cancer prevention and treatment. Examples of recent agents under investigation include Cranberry Proanthocyanidins, Mito-Lonidamine, Mito-Honokiol, Mito-Magnolol, Vitamin D, the NSAID sulindac alone and in combination with ranitidine. Dr. Kresty’s lab utilizes a combination of genetic, pharmacologic, and standard molecular biology techniques for combined with a battery of high-throughput platforms for target identification, understanding cancer-host interactions and investigating cancer inhibitory signaling mechanisms. Panels of human cancer cell lines, primary cultures, stem cell cultures, as well as rodent models, including a rat surgical model of acid reflux-induced esophageal adenocarcinoma are routinely employed prior to translating the evaluation of promising agents into early phase trials in high risk human cohorts.
Dr. Kresty has Editorial responsibilities for Molecular Carcinogenesis, Clinical Nutrition, a Specialty of Frontiers in Nutrition, The Journal of Clinical Investigation Insight and is a peer reviewer for multiple additional journals in her field. She is a Standing Member of the National Cancer Institute’s Cancer Prevention Study Section and has served on numerous additional NCI, NIDDK, and NCCAM Review Sections since 2009. Dr. Kresty is a member of the Cancer Epidemiology and Prevention Program within the University of Michigan Rogel Cancer Center.
Dr. Kresty has Editorial responsibilities for Molecular Carcinogenesis, Clinical Nutrition, a Specialty of Frontiers in Nutrition, The Journal of Clinical Investigation Insight and is a peer reviewer for multiple additional journals in her field. She is a Standing Member of the National Cancer Institute’s Cancer Prevention Study Section and has served on numerous additional NCI, NIDDK, and NCCAM Review Sections since 2009. Dr. Kresty is a member of the Cancer Epidemiology and Prevention Program within the University of Michigan Rogel Cancer Center.
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bioRxiv : the preprint server for biology (2024)
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Yun Zhang,Katherine M. Weh,Bridget A. Tripp,Jennifer L. Clarke,Connor L. Howard, Shruthi Sunilkumar,Amy B. Howell,Laura A. Kresty
Pharmaceuticalsno. 12 (2023): 1697
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