基本信息
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Bio
Research Interests
The roles of the amyloid precursor protein (APP) interacting proteins in Alzheimer's disease
The role of APP in gene regulation
Molecular pathogenesis of neurodegeneration
Representative Publications
Chow WNV, Ngo JCK, Li W, Chen YW, Tam KMV, Chan HYE, Miller CCJ and Lau KF (2015) Phosphorylation of FE65 Serine-610 by serum- and glucocorticoid-induced kinase 1 modulates Alzheimer’s disease amyloid precursor protein processing. Biochemical Journal 470, 303-317.
Chow WNV, Cheung HNM, Li Wen and Lau KF (2015) FE65: roles beyond amyloid precursor protein processing. Cellular & Molecular Biology Letters 20, 66-87.
Stoica R, De Vos KJ, Paillusson S, Mueller S, Sancho R, Lau KF, Vizcay-Barrena G, Lin WL, Xu F, Lewis J, Dickson D, Petrucelli L, Mitchell J, Shaw CE and Miller CCJ (2014) ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by FTD/ALS-associated TDP-43. Nature Communications 5, 3996. doi:10.1038/ncomms4996.
Cheung HN, Dunbar C, Mórotz GM, Cheng WH, Chan HY, Miller CC, Lau KF (2014) FE65 interacts with ADP-ribosylation factor 6 to promote neurite outgrowth. FASEB J 28, 337-349.
Chow WNV, Luk HW, Chan HYE and Lau KF (2012). Degradation of mutant huntingtin via ubiquitin-proteasome system is modulated by FE65. Biochemical Journal 443, 681-689.
Tsoi H, Lau TC, Tsang SY, Lau KF and Chan HY (2012) CAG expansion induces nucleolar stress in polyglutamine diseases. Proc Natl Acad Sci USA 109, 13428-13433.
Li M, Choi ST, Tsang KS, Shaw PC and Lau KF (2012) DNA Microarray Expression Analysis of Baicalin-induced Differentiation of C17.2 Neural Stem Cells. Chembiochem 18, 1286-1290.
Ng AKL, Chan WH, Choi ST, Lam MKH, Lau KF, Chan PKS, Au SWN, Fodor E and Shaw PC (2012) Influenza Polymerase Activity Correlates with the Strength of Interaction between Nucleoprotein and PB2 through the Host-Specific Residue K/E627. PLoS ONE 7(5): e36415. doi:10.1371/journal.pone.0036415.
Manser C, Guillot F, Vagnoni A, Davies J, Lau KF, McLoughlin DM, De Vos KJ and Miller CCJ (2012) Lemur tyrosine kinase-2 signalling regulates kinesin light chain-2 phosphorylation and binding of Smad2 cargo. Oncogene 31, 2733-2782.
Chai KH, McLoughlin DM, Chan TF, Chan HYE and Lau KF (2011) Genomic organization and promoter cloning of the human X11a gene APBA1. DNA and Cell Biology 31, 651-659.
Tsoi H, Lau CK, Lau KF and Chan HY (2011) Perturbation of U2AF65/NXF1-mediated RNA nuclear export enhances RNA toxicity in polyQ diseases 1. Human Molecular Genetics 20, 3787-3797.
Hao Y, Perkinton MS, Chan WW, Chan HYE, Miller CC and Lau KF (2011) GULP1 is a novel APP interacting protein that alters APP processing. Biochemical Journal 436, 631-639.
Chan WM, Tsoi H, Wu CC, Wong CH, Cheng TC, Li HY, Lau KF, Shaw PC, Perrimon N and Chan HYE (2011) Expanded polyglutamine domain possesses nuclear export activity which modulates subcellular localization and toxicity of polyQ disease protein via exportin-1. Human Molecular Genetics 20, 1738-1750.
Li M, Tsang KS, Choi ST, Li K, Shaw PC and Lau KF (2011) Neuronal Differentiation of C17.2 Neural Stem Cells Induced by a Natural Flavonoid, Baicalin. Chembiochem 12, 449-456.
Yu HT, Chan WW, Chai KH, Lee CW, Chang RC, Yu MS, McLoughlin DM, Miller CC and Lau KF (2010) Transcriptional regulation of human FE65, a ligand of Alzheimer's disease amyloid precursor protein, by Sp1. Journal of Cellular Biochemistry 109, 782-793.
Lau KF* (*corresponding author), Chan WM, Perkinton MS, Tudor EL, Chang RC, Chan HY, McLoughlin DM and Miller CC (2008) Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein dependent transcription. Journal of Biological Chemistry 283, 34728-34737.
Research Interests
Papers共 117 篇Author StatisticsCo-AuthorSimilar Experts
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Neural regeneration researchno. 10 (2023): 2186-2187
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Signal Transduction and Targeted Therapy (2023)
Biochemical Society transactionsno. 4 (2023): 1647-1659
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Author Statistics
#Papers: 117
#Citation: 4193
H-Index: 34
G-Index: 63
Sociability: 6
Diversity: 3
Activity: 42
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