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个人简介
Dr. Landfear moved to OHSU as an Assistant Professor in the Department of Molecular Microbiology & Immunology 1987 where he initiated studies on the developmental regulation of gene expression in Leishmania parasites. The laboratory soon began to focus on glucose transporters as developmentally regulated genes that played central roles in the physiology of the parasite and in its ability to take up critical nutrients from its hosts. His laboratory subsequently proceeded to study other important transporters from Leishmania and African trypanosomes, including the cloning of the genes for purine nucleoside and nucleobase transporters, purines being critical nutrients that the parasite cannot synthesize and must import from its hosts. Studies on transporters have also led to investigating mechanisms for specialized targeting of integral membrane proteins in these parasites, especially targeting of transporters and channels to the flagellar membrane of Leishmania and African trypanosomes and the roles such flagellar membrane proteins play in sensing the changing environment of the parasites.
研究兴趣
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Papireddy Kancharla,Diana Ortiz,Corinne M. Fargo, Xiaowei Zhang,Yuexin Li,Marco Sanchez, Amrendra Kumar, Monish Yeluguri,Rozalia A. Dodean,Diana Caridha,Michael S. Madejczyk,Monica Martin,
JOURNAL OF MEDICINAL CHEMISTRYno. 10 (2024): 8323-8345
Journal of medicinal chemistryno. 11 (2023): 7374-7386
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWSno. 2 (2020)
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