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The goal of my research is to understand the biology underlying the host-pathogen interactions in tuberculosis, and to translate these findings to treatment of human disease. I am a practicing clinician, specializing in infectious diseases and my fundamental research is framed in the context of clinical TB. To this end, my laboratory developed and validated a Mycobacterium marinum-zebrafish model of TB pathogenesis. We have made several surprising discoveries about TB pathogenesis and drug tolerance, and we have led the field by challenging fundamental assumptions about the mechanisms of drug tolerance, and the role of the tuberculous granuloma and of inflammation in pathogenesis. Key discoveries have been validated by us or others in human studies, and suggest completely new approaches to TB treatment.
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M Alexandra Lake,Kristin N. Adams, Feilin Nie,Elaine Fowler,Amit Verma,Silvia Dei,Elisabetta Teodori,David R. Sherman,Paul H. Edelstein,David R. Spring,Mark Troll,Lalita Ramakrishnan
Proceedings of the National Academy of Sciences of the United States of Americano. 7 (2023)
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