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The Turka Laboratory in the Center for Transplantation Sciences (CTS) at Massachusetts General Hospital investigates three major research areas. The first program researches the role of CD28 in Treg development. Our laboratory was the first to demonstrate that the blockade of CD28 signals can prevent allograft rejection. Using new conditional CD28 knockout mice generated in our lab, and various Cre strains, we are examining the role of CD28 in Treg development, conversion and survival, and CD28’s importance for maintaining established T effector-driven immune responses, including transplantation, autoimmunity and helper-dependent antibody production.
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JOURNAL OF CLINICAL INVESTIGATIONno. 1 (2024)
Patrick Ho,Ellen Cahir-McFarland,Jason D. Fontenot, Tracey Lodie, Adel Nada,Qizhi Tang,Laurence A. Turka,Jeffrey A. Bluestone
SCIENCE TRANSLATIONAL MEDICINEno. 738 (2024): eadm8859-eadm8859
CANCER RESEARCHno. 12 (2022)
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Cancer Researchno. 12_Supplement (2022): CT187-CT187
Alexander I. Spira,Melissa Lynne Johnson, Ai Ren, Varsha Sundaresan, Ines Verdon,Laurence Turka,Sivan Elloul
Mengyao Luo, Shamael S. Dastagir,Xuqing Zhang,Andrea Schmidt,Beatriz Marques,Timothy J. Lyford, Billy Blanco,Laurence A. Turka,Thomas J. Wickham,Tiffany F. Chen
Journal for ImmunoTherapy of Cancerno. Suppl 2 (2021): A219-A219
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