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Research interests
Inflammation and inflammatory diseases such as chronic obstructive pulmonary disease or rheumatoid arthritis are extremely difficult to treat effectively. During inflammation, inflammatory cells, in particular neutrophils and monocytes, are thought to be key mediators of both tissue damage and perpetuation of further inflammatory signalling. My research focuses on the role of neutrophils during infection and inflammation and how their inflammatory potential and function is regulated by cell death programme, in particular, apoptosis and NETosis. We are currently studying whether an orally active protein kinase C beta inhibitor (ruboxistaurin) and a clinical EGFR/ErbB inhibitor (neratinib) have therapeutic potential in lung and cardiovascular diseases.
Research Interests
Papers共 58 篇Author StatisticsCo-AuthorSimilar Experts
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Clare F Muir,Constantino Carlos Reyes-Aldasoro,Felix E Ellett,Tomasz K Prajsnar,Yin X Ho,Audrey Bernut,Catherine A Loynes,Stone Elworthy, Kieran A Bowden, Ashley J Cadbury,Lynne R Prince,Jason S King,
biorxiv(2024)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Encyclopedia of Respiratory Medicine (2022)
Kimberly D Herman,Carl G Wright,Helen M Marriott, Sam C McCaughran,Mark Collins,Stephen A Renshaw,Lynne R Prince
medRxivpp.00596-2021, (2021)
Frontiers in cell and developmental biology (2021): 636024-636024
Frontiers in immunology (2021): 678771-678771
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