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个人简介
Dr. Le is a Dermatologist with a scientific focus on neural-crest derived tissue development, regeneration and tumorigenesis, in particular the biology of neurofibromatosis. He graduated from the Medical Scientist Training Program at University of California, Los Angeles and completed residency training in Dermatology and a postdoctoral research fellowship in Cancer Biology from University of Texas Southwestern Medical Center. He is a professor of dermatology and holds the Thomas L. Shield, M.D. Professorship in Dermatology at UT Southwestern. As a principal investigator in Cancer Biology, Dr. Le’s laboratory investigates how tumor cell of origin and tumor microenvironment interplay to regulate neurofibromatosis-associated tumorigenesis. A major contribution of Dr. Le’s laboratory is the generation and exploitation of novel neurofibromatosis models to decipher mechanisms that initiate Schwann cell tumor development and drive their malignant transformation. It was this work in neurofibromatosis and mechanisms whereby neural-crest derived tissues and nerves can affect tumor development in skin and other tissues that serendipitously lead Dr. Le’s research group to uncover the identity of follicular epithelial cells that directly give rise to hair and mechanisms that cause hair to turn gray – findings that could one day help identify possible treatments for balding and hair graying.
研究兴趣
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Journal of Clinical and Translational Scienceno. s1 (2024): 115-115
JOURNAL OF INVESTIGATIVE DERMATOLOGYno. 5 (2023): S142-S142
Journal of Investigative Dermatologyno. 8 (2022)
Journal of Investigative Dermatologyno. 8 (2022): S128-S128
S. Verma,S. Gosline,S. Peltonen,J. Peltonen, A. Soragni,P. Wallace,L. Le, P. Topilko,D. Gutmann, C. Anastasaki,R. Mattingly,E. Serra,
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