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He was a member of the Johns Hopkins team that produced the first high-resolution images of antibody-antigen recognition, the body’s reaction to fighting off disease and illness. His early work to crystalize and determine the structure of an antibody was of seminal importance in immunology.
Dr. Amzel’s research also involved the cancer-related protein PI3K, which is part of the body’s hormone signaling system. He worked to understand PI3K’s structure, its normal state and how cancer mutations inappropriately activate it. In addition, his research led to major discoveries to determine how proteins navigate sodium channels in cardiac cells, a key factor in enabling the heart to beat.
More recently, Dr. Amzel’s lab had been developing computational methods to calculate the changes that occur when a protein recognizes another macromolecule or a small ligand, a key factor in how medicines bind to their targets.
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The journal of physical chemistry. Bno. 7 (2023): 1540-1551
Lakshmi Srinivasan,Vanina Alzogaray,Dakshnamurthy Selvakumar,Sara Nathan,Jesse B. Yoder,Katharine M. Wright,Sebastián Klinke, Justin N. Nwafor, María S. Labanda,Fernando A. Goldbaum,Arne Schön,Ernesto Freire,
Lakshmi Srinivasan,Mario A. Pizarro Dupuy,P. Aitana Azurmendi, Allister Allister Suarez,Krisna C. Duong-Ly,Jesse B. Yoder, Akunna M. Iheanacho,Andrew J. Schoeffield,Mario Amzel,Silvia A. Pineiro,Sandra B. Gabelli
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