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个人简介
My research revolves around metabolism and the heart – understanding why metabolism is important and what the consequences are when it goes wrong.
My passion for metabolism began during my undergraduate degree in Medical Biochemistry at the University of Surrey. I loved the way everything fitted together into this complex jigsaw, which in many ways resembled the London Underground map. And just like a public transport network, if something goes wrong with one enzyme or pathway, the whole system can either adapt or grind to a halt.
I joined the Department in 2003 as a DPhil student of Prof Kieran Clarke. My doctoral research investigated the role of abnormal substrate metabolism in the development of cardiac hypertrophy. My subsequent post-doctoral research focused on the role of mitochondrial metabolism in cardiac disease progression.
In 2011 I was awarded a Diabetes UK RD Lawrence Fellowship, to study the role of hypoxia and metabolism in the type 2 diabetic heart. Heart disease is the leading cause of mortality in patients with type 2 diabetes, and patients have increased incidence of, and decreased recovery following myocardial infarction.
In 2018 I was awarded a British Heart Foundation Intermediate Fellowship, to study why fat accumulation in the diabetic heart is such a bad thing. We are studying what fats can do to the function of the cardiomyocyte, and how they might be signalling to activate deleterious processes.
My passion for metabolism began during my undergraduate degree in Medical Biochemistry at the University of Surrey. I loved the way everything fitted together into this complex jigsaw, which in many ways resembled the London Underground map. And just like a public transport network, if something goes wrong with one enzyme or pathway, the whole system can either adapt or grind to a halt.
I joined the Department in 2003 as a DPhil student of Prof Kieran Clarke. My doctoral research investigated the role of abnormal substrate metabolism in the development of cardiac hypertrophy. My subsequent post-doctoral research focused on the role of mitochondrial metabolism in cardiac disease progression.
In 2011 I was awarded a Diabetes UK RD Lawrence Fellowship, to study the role of hypoxia and metabolism in the type 2 diabetic heart. Heart disease is the leading cause of mortality in patients with type 2 diabetes, and patients have increased incidence of, and decreased recovery following myocardial infarction.
In 2018 I was awarded a British Heart Foundation Intermediate Fellowship, to study why fat accumulation in the diabetic heart is such a bad thing. We are studying what fats can do to the function of the cardiomyocyte, and how they might be signalling to activate deleterious processes.
研究兴趣
论文共 127 篇作者统计合作学者相似作者
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Antiviral research (2024): 105933-105933
Diabetesno. 5 (2024): 659-670
PHYSIOLOGICAL REVIEWSno. 2 (2024): 727-764
EXPERIMENTAL PHYSIOLOGYno. 6 (2023): 874-890
Metabolism Open (2022): 100177
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2022): S125-S125
Surgery (Oxford)no. 4 (2022): 219-226
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作者统计
#Papers: 129
#Citation: 3944
H-Index: 32
G-Index: 61
Sociability: 6
Diversity: 0
Activity: 1
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