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My current research aims to identify how respiratory viruses infect and trigger proinflammatory responses in airway epithelial cells and to determine how the responses that are generated may be modified. Pathogens are detected by Toll-Like receptors (TLRs), a family of receptors that regulate cell activation, however the mechanisms through which pathogens initiate airway exacerbations remain inadequately defined. A more complete understanding of the host innate immune responses and the complex signalling pathways that are triggered by viral pathogens is crucial, as viruses are a major trigger of acute exacerbations in asthma and chronic obstructive pulmonary disease (COPD).
Research Interests
Papers共 57 篇Author StatisticsCo-AuthorSimilar Experts
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Encyclopedia of Respiratory Medicine (2022)
Jake T Mills,Anja Schwenzer,Elizabeth K Marsh, Michael R Edwards,Ian Sabroe,Kim S Midwood,Lisa C Parker
C A Stokes,R Kaur,M R Edwards, M Mondhe,D Robinson, E C Prestwich,R D Hume, C A Marshall,Y Perrie,V B O'Donnell,J L Harwood,I Sabroe,
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