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个人简介
Dr. Wong's major research interest is to decipher the molecular pathogenesis of ovarian cancer with a translational goal to identify potential prognostic biomarkers and therapeutic targets for individualized therapy. Both genomics and mouse model approaches are being pursued in his laboratory. Ovarian cancer is a heterogeneous disease with complex molecular and genetic changes. There are five major histological subtypes of epithelial ovarian cancer: high-grade serous carcinoma (HGSC), low-grade serous carcinoma (LGSC), ovarian clear cell carcinoma (OCCC), mucinous epithelial ovarian carcinoma, and ovarian endometrioid carcinoma. Mutations in several genes have been identified as contributing to various ovarian cancer subtypes. TP53 mutations are present in almost all HGSCs, and BRCA1/2 mutations are present in approximately 10% of HGSCs. However, other actionable mutations are infrequent in HGSCs. On the other hand KRAS activating mutations are present in more than 30% of LGSCs and more than 40% of mucinous ovarian carcinomas. PIK3CA activating mutations are present in more than 35% of OCCCs and more than 20% of ovarian endometrioid carcinomas. BRAF activating mutations are detected in both LGSCs (2-33%) and mucinous ovarian carcinomas (~10%). ARID1A, the AT-rich interactive domain A1 gene, is mutated in more than 45% of OCCCs and more than 25% of ovarian endometrioid carcinomas. Thus, there are many opportunities to develop targeted therapies for these specific histological subtypes with actionable mutations.
研究兴趣
论文共 254 篇作者统计合作学者相似作者
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Christopher M. Tarney,Paulette Mhawech-Fauceglia, Jonathan Ogata,Julie Oliver,Tamara Abulez,Brian L. Hood,Kelly A. Conrads, Kendal Rosalik,Kwong-Kwok Wong,David M. Gershenson,Sanghoon Lee,Anil K. Sood,
crossref(2024)
Warapen Treekitkarnmongkol,Luisa M. Solis, Deivendran Sankaran,Mihai Gagea, Pankaj K. Singh,Ragini Mistry, Tristian Nguyen,Kazuharu Kai, Jiajun Liu,Kaori Sasai,Yoshimi Jitsumori,Jianwen Liu,
SCIENCE SIGNALINGno. 826 (2024): eadh4475-eadh4475
Cancer Researchno. 6_Supplement (2024): 7662-7662
crossref(2023)
crossref(2023)
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