基本信息
浏览量:34
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
个人简介
Our group is interested in how the ribosome works. The ribosome is a large (~2.5 MDa), two-subunit, RNA-based machine that translates the genetic code in all organisms. In recent years, numerous structures of the ribosome and various ribosomal complexes have been determined by X-ray crystallography and cryo-electron microscopy. Today, a primary challenge is to understand how the ribosome moves and how such dynamics govern the various steps of translation. Since the ribosome is the most common target of natural antibiotics, gaining insight on ribosome function may contribute substantially to the development of new antibiotics.
We use a combination of genetic, molecular, and biochemical methods to study protein synthesis in bacteria. Examples of questions under investigation in the laboratory include: (1) Which features of mRNA tune the rate of initiation? (2) How do mechanisms of initiation compare in different phyla? (3) How do rRNA dynamics contribute to the mechanism of decoding (aminoacyl-tRNA selection)? (4) What roles do nonessential ribosome-associated GTPases play in the cell? (5) How do elements of precursor rRNA contribute to subunit assembly?
We use a combination of genetic, molecular, and biochemical methods to study protein synthesis in bacteria. Examples of questions under investigation in the laboratory include: (1) Which features of mRNA tune the rate of initiation? (2) How do mechanisms of initiation compare in different phyla? (3) How do rRNA dynamics contribute to the mechanism of decoding (aminoacyl-tRNA selection)? (4) What roles do nonessential ribosome-associated GTPases play in the cell? (5) How do elements of precursor rRNA contribute to subunit assembly?
研究兴趣
论文共 98 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
RNAno. 2 (2024): 136-148
Nucleic acids researchno. 10 (2023): 5242-5254
Journal of molecular biologyno. 19 (2020): 5259-5272
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn