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个人简介
My new name is Tami Green(2020.5.19). Citizenship is Swedish(2020.05.11) and I am Senior Research Engineer from the Umeå Centre for Molecular Medicine. My initial research as a Project Associate with Ass. Prof. Suvro Chatterjeer Au-Kbc at Research Centre (2003-2007), focused on mechanisms of metabolic diseases on vascular tissue. I analysed the influence of hypoxia, thalidomide and cadmium on nitric oxide mediated angiogenesis. This work lead to 8 publications, including 2 first and 2 second authorships. My first research showed the use of thalidomide with cell biology models and proved the use of thalidomide mediated antiangiogenesis to treat cancer. This work was published in BMC Cell Biology where I am first author (2006). In 2007, I was selected for an international Ph.D program in Molecular Medicine in Austria, in the research group of Prof. Gerald Hoefler, Medical University of Graz, one of the leading scientific groups in lipidomics and cancer. During this time, I examined the lipotoxic effects on skeletal muscle using myoblast cell lines and transgenic mouse models, which overexpressed muscle-specific human lipoprotein lipase in heart and skeletal muscles. The results of this study supported the concept of lipotoxicity, which might explain the pathophysiological effects observed in the muscles of obese patients, patients with metabolic syndrome and patients with cancer-associated cachexia. This work was published in the Journal of Cell Death and Disease where I am first author (2012). Another part of my thesis work, published in Science (2011), concerned adipose triglyceride lipase in cancer associated cachexia by subcutaneous injection of tumor cells in mice, followed by analysed tumor growth. In 2014, I successfully defended my PhD-work, and in 2015 I started postdoc research with Prof. Lena Gunhaga, UCMM, Umeå University, with work spanning processes in both development and cancer. A major project concerned the role of Sox2 during early development of the olfactory epithelial development and neurogenesis within. This publication, in Development, 2018 were I am first author, I was the first to show that an in ovo electroporated chick CRISPR/Cas9:Sox2 editing construct mimicked the phenotype of a corresponding FoxG1:Sox2 transgenic mouse. In addition, I published as first author in Differentiation (2019), results describing migratory Isl1, Lhx2 and GnRH neuronal subpopulations from the olfactory epithelium involved in the formation of a terminal nerve ganglion. With all my experience, I independently created and carried out a project that explains how to visualize and quantify metastatic aggressiveness in human or other mammalian cancer cells. This work was accepted in the Scientific reports (2020) where I contributed as first author and I have shared equal corresponding author. In this project, I have established genetically engineered human cancer cells by CRISPR/ Cas9-D10A (Prostate cancer, Colon cancer, Lung cancer and Glioblastoma) and visualized the metastatic behavior. Moreover, my recent publication from the Journal of Visualized Experiments (2022) explains the use of Chorioallantoic membrane from chicken as model system to study delamination. Currently, I have achieved 14 international peer-reviewed publications.
研究兴趣
论文共 14 篇作者统计合作学者相似作者
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Sandra Eder,Silvia Schauer,Clemens Diwoky, Hannes Temmel,Barbara Guertl,Gregor Gorkiewicz,Kuppusamy P. Tamilarasan,Pooja Kumari, Michael Trauner, Robert Zimmermann,Paul Vesely,Guenter Haemmerle,
semanticscholar(2013)
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