Dr K. M. CHAN graduated with BSc and received his PhD at the Department of Biochemistry, HKU. He then moved to Mayo Clinic (Rochester MN, USA) for postdoctoral training and obtained the Edward C. Kendall Research Fellowship in Biochemistry before rejoining HKU as Research Assistant Professor in June 2013. In February 2015 he joined the Department of Biomedical Sciences (BMS), City University of Hong Kong as a tenure-track Assistant Professor.

Research Interests
Dr Chan is interested in understanding 1) the role of epigenetics in regulating gene expression and human diseases and 2) how epigenetic information in maintained during cell division. It is well known that genetic information is encoded by the DNA sequence. However, DNA alone does not account for the complexity of the mammalian genome. Chromatin, comprising DNA, core histones and other regulatory proteins, regulates gene expression and maintains genome stability. Recent studies including ours have used the next generation sequencing technologies and the CRISPR-Cas9 approach to elucidate the mechanisms of mutant histones in the development of brain and bone cancers. We are currently focusing on identifying new cancer driving histone mutations and discovering therapeutics for these diseases using different animal models.