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个人简介
Under the DARPA SPARTA program, I developed an innovative proteomic mass spectrometry platform with capabilities for small molecule early exploratory target identification. This technology is ideal for target identification in a drug discovery pipeline. Relevant methodologies include the identification of novel targets, small molecule target deconvolution, direct protein substrate identification and characterization, protein post-translation modification studies, and small molecule-protein interactome analyses.
General understanding of target deconvolution methods including iTSA, CETSA, DARTS, and chemical probes/proteomics. Experience and knowledge in the operation and maintenance of different types of mass spectrometers including Q Exactive Hybrid Quadrupole and Orbitrap Fusion Tribrid. Extensive knowledge and application of complex sample preparation methodologies as applied to protein mass spectrometry workflows. Ability to characterize protein post-translational modifications including phosphorylation, methylation, acetylation, and ubiquitination. Expertise in implementing quantitative mass spectrometry-based strategies including isotopic labeling, isobaric tagging (TMT), SILAC, and label-free analysis (DIA, PRM/SRM) methods. Applied knowledge with MS software analysis pipelines including IP2, Proteome Discoverer, MaxQuant, and Skyline. General understanding of chemical proteomics methodologies including affinity enrichment. Ability to script in the R language for statistical analysis, data cleaning, and the detection of batch effects. I have the ability to complete and effectively manage multiple projects within timelines ensuring that all tasks and responsibilities are carried out according to high scientific and ethical standards.
研究兴趣
论文共 52 篇作者统计合作学者相似作者
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Carlos A. M. Silva,Barbara G. Graham,Kristofor Webb,M. Nurul Islam, Marisa Harton,Maria Angela de Mello Marques,Fernanda Marques de Carvalho, Roberta Olmo Pinheiro,John Spencer, Euzenir Nunes Sarno, Geraldo Batista M. Pereira,Maria Cristina Vidal Pessolani,
ACS INFECTIOUS DISEASESno. 8 (2023): 1458-1469
MOLECULAR & CELLULAR PROTEOMICSno. 10 (2022): 100262-100262
biorxiv(2020)
Yonghui Ding,Kerri A. Ball,Kristofor J. Webb,Yu Gao, Angelo D'Alessandro,William M. Old,Michael H. B. Stowell,Xiaoyun Ding
Smallno. 41 (2020)
Kerri A. Ball,Kristofor J. Webb,Stephen J. Coleman, Kira A. Cozzolino,Jeremy Jacobsen, Kevin R. Jones,Michael H. B. Stowell,William M. Old
Carlos A M Silva,Barbara Graham,Kristofor Webb,Laura Vari Ashton,Marisa Harton,Annie F Luetkemeyer, Samantha Bokatzian, Reem Almubarak,Sebabrata Mahapatra,Laura Hovind,Michelle A Kendall,Diane Havlir,
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