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个人简介
My research focus is on environmental, chemically induced neurodegenerative processes capable of producing CNS disorders such as Parkinson’s and Alzhimer’s Disease. I have made several fundamental advances in signal transduction mechanisms associated with cell death processes by exposure to the chemicals such as cyanide and manganese. Mitochondrial dysfunction is an early event in the neurodegenerative processes induced by these select agents. Reduced ATP levels, increased reactive oxygen species (ROS), impaired calcium homeostasis, and altered mitochondrial permeability are characteristic mitochondrial defects (Prabhakaran et al., 2005). In many neurodegenerative disorders, specific subsets of neurons degenerate while others are unaffected. Despite the clear association of mitochondrial dysfunction with neurodegenerative disease the molecular mechanisms of selective vulnerability are poorly understood. The primary focus of my research is on selective vulnerability of the nervous system to neurotoxic agents such as Cyanide, Manganese and Particulate Matter including Nano Materials. and identification of novel therapeutic agents to treat neurodegenerative conditions.
研究兴趣
论文共 44 篇作者统计合作学者相似作者
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Nicole Nazario Bayon,Nithin Krisshna Gunasekaran,Prathima Prabhu Tumkur, Babu R. Lamani,Jessica E. Koehne, Wondwossen D. Arasho,Krishnan Prabhakaran,Joseph C. Hall,Govindarajan T. Ramesh
MATERIALS EXPRESSno. 9 (2022): 1211-1215
Nanomanufacturingno. 3 (2021): 176-189
Journal of Nanosciences Research & Reportspp.1-5, (2020)
Frontiers in Neuroscience (2019)
Hirendra N. Banerjee,Jameel Joyner,Alexis Barfield,B Morris,D Bell, William Kahan, Monet Stevenson, D Crummity,K Prabhakaran,Santosh K. Mandal,Fazlul H. Sarkar
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