Our principal research interests are in genetic and molecular endocrinology, with particular emphasis on disorders nuclear hormone synthesis and action. We study Resistance to Thyroid Hormone due to defective thyroid hormone receptor beta or alpha.  Candidate gene and whole exome approaches are used to identify novel genetic aetiologies mediating defective hormone action.  Human phenotypic studies elucidate mechanisms whereby thyroid hormones alter physiological processes acting via receptor subtypes in tissues.  In a multisystem selenoprotein deficiency disorder including thyroid deiodinase enzymes, we are investigating features (cardiovascular, metabolic, photosensitivity) attributable to elevated ROS and the roles of selenoproteins of unknown function.  Finally, we translate our research into technologies (biochemical, genetic) that comprise an internationally renowned diagnostic laboratory service, develop biomarkers of hormone action and trial therapies (e.g. selective thyromimetics) that are applicable to commoner forms of thyroid dysfunction or other metabolic disorders.