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个人简介
The origin of life remains one of the fundamental questions in modern biology. The mystery lies in how the transition was made from the prebiotic world of inanimate chemicals to the Central Dogma-based biological system. At the heart of the issue is how RNA chain and polypeptides arose from the chemical disequilibria, interacted, and ultimately led to a functioning biological system. My previous works were centered on transfer RNA, known as the molecular fossil that decodes genetic information on a nucleotide chain to an amino acid. In other words, tRNA is a molecule that bridges the gap between the generally accepted RNA world (RNA based biological system) and modern biology. Most attempts to understand the origin of life so far focus on RNA and hardly any work has been done on synthesizing abiotically produced short peptides that are likely existed earlier than chain of nucleotides on early Earth, let alone extraterrestrial environments. Hence, my research is centered on testing the ‘peptide-first hypothesis’ by synthesizing a large pool of de novo peptides and proteins in an in vitro system to understand their function, evolution and heredity prior to the emergence of genetic system. These challenging researches will became part of a role model for the emerging field of “Synthetic Astrobiology”.
研究兴趣
论文共 70 篇作者统计合作学者相似作者
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Jaime Cesar,Brooke Dallas,Laura Chimiak, Kliti Grace,Matthieu Clog,Michael Lawson,Max Lloyd,Alison Piasecki, Camilo Ponton,Hao Xie,Jens Griep-Raming,Dieter Juchelka,
crossref(2024)
Simone Codispoti, Tomoko Yamaguchi,Mikhail Makarov,Valerio G. Giacobelli, Martin Mašek,Michal H. Kolář, Alma Carolina Sanchez Rocha,Kosuke Fujishima, Giuliano Zanchetta,Klára Hlouchová
biorxiv(2024)
Shota Nishikawa, Wen-Chi Yu,Tony Z. Jia, Ming-Jing He,Anna Khusnutdinova,Alexander F. Yakunin,Yin-Ru Chiang,Kosuke Fujishima,Po-Hsiang Wang
ACS Catalysispp.7696-7706, (2024)
Shota Nishikawa, Wen-Chi Yu,Tony Z. Jia, Ming-Jing He,Anna Khusnutdinova,Alexander F. Yakunin,Yin-Ru Chiang,Kosuke Fujishima,Po-Hsiang Wang
ACS CATALYSISno. 10 (2024): 7696-7706
SCIENCE ADVANCESno. 50 (2023): eadh7845-eadh7845
bioRxiv (Cold Spring Harbor Laboratory) (2023)
BIOMACROMOLECULESno. 1 (2023): 355-365
SCIENCEno. 6677 (2023): 1411-1415
ACS synthetic biologyno. 10 (2023): 2887-2896
GREEN CHEMISTRYno. 23 (2023): 9896-9907
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