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The Kodadek laboratory works in the general area of chemical biology with an emphasis on translational research. The laboratory employs a broad spectrum of techniques that span organic chemistry to molecular genetics. Several projects focus on novel methods to monitor and manipulate the immune system. One goal of these efforts is to discover effective and early diagnostic tests for a variety of disease states, including cancers, autoimmune diseases and neurodegenerative conditions. Another is to identify compounds that act as “antigen surrogates” in that they have the ability to recognize the antigen-binding sites of antibodies and T cell receptors. These compounds are being developed as potential therapeutic agents to block autoimmune responses selectively without interfering with the healthy functioning of the immune system. Another major project area is to develop better libraries and more efficient screening technologies for the discovery of protein ligands and bioactive compounds. For example, new classes of oligomeric, bio-inspired compounds are being created and new methods that will allow the rapid screening of tens of millions of compounds at a time are being developed.
Finally, the Kodadek laboratory is interested in understanding the biology of many of the systems that are being targeted pharmacologically. For example, one project aims to understand the biochemical mechanisms underlying orexin signaling, which triggers wakefulness in mammals. Another seeks to better understand the role of the proteasome in transcriptional regulation.
Diseases that are under investigation include Alzheimer's disease, Neuromyelitis Optica, Multiple Sclerosis, Pancreatic Cancer, Narcolepsy, Chronic Lymphoid Leukemia and various other cancers.
Finally, the Kodadek laboratory is interested in understanding the biology of many of the systems that are being targeted pharmacologically. For example, one project aims to understand the biochemical mechanisms underlying orexin signaling, which triggers wakefulness in mammals. Another seeks to better understand the role of the proteasome in transcriptional regulation.
Diseases that are under investigation include Alzheimer's disease, Neuromyelitis Optica, Multiple Sclerosis, Pancreatic Cancer, Narcolepsy, Chronic Lymphoid Leukemia and various other cancers.
Research Interests
Papers共 500 篇Author StatisticsCo-AuthorSimilar Experts
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Journal of the American Chemical Societyno. 21 (2024): 14633-14644
Priscila M S Castanha,Patrick J McEnaney,Yongseok Park, Anthea Bouwer, Elton J F Chaves,Roberto D Lins,Nicholas G Paciaroni,Paige Dickson, Graham Carlson,Marli T Cordeiro,Tereza Magalhaes, Jodi Craigo,
Proceedings of the National Academy of Sciences of the United States of Americano. 21 (2024): e2312755121-e2312755121
CHEMISTRY-A EUROPEAN JOURNALno. 2 (2024): e202302937-e202302937
Chembiochem : a European journal of chemical biologyno. 18 (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
crossref(2023)
crossref(2023)
ACS chemical biologyno. 7 (2023): 1582-1593
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