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We are studying the interactions of neurons and glial cells in the mammalian nervous system with a special interest in the role of oligodendrocytes and Schwann cells, best known as myelin forming cells of the central and peripheral nervous system. These highly specialized glial cells enwrap axons with a multilayered sheath that provides electrical insulation for rapid impulse propagation.
However the biology of these axon-glia interactions is complex. Using mouse genetics, originally to study the role of proteins in the myelin architecture and in neurogenetic disorders, we made the unexpected discovery of a novel function of oligodendrocytes, which even precedes myelin in nervous system evolution: the glial metabolic support of axonal conduction, axonal transport and long-term integrity. We determined that oligodendrocytes and Schwann cells take up glucose and deliver lactate, here the product of aerobic glycolysis, to the axonal compartment. This supportive function helps maintaining axon functions especially when ATP demands are increased at higher firing rates, also because access of axons to extracellular metabolites is restricted by myelin itself.
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论文共 296 篇作者统计合作学者相似作者
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Vinicius Daguano Gastaldi, Justus BH Wilke, Cosima A. Weidinger, Carolin Walter,Nadine Barnkothe,Bianca Teegen,Felix Luessi,Winfried Stöcker,Fred Lühder, Martin Begemann,Frauke Zipp,Klaus-Armin Nave,
Brain, Behavior, and Immunity (2023): 135-147
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Erik Schäffner, Mar Bosch-Queralt,Julia M. Edgar, Maria Lehning,Judith Strauß, Niko Fleischer,Theresa Kungl,Peter Wieghofer,Stefan A. Berghoff,Tilo Reinert,Martin Krueger,Markus Morawski,
biorxiv(2023)
Vinicius Daguano Gastaldi,Justus BH Wilke, Cosima A. Weidinger, Carolin Walter,Nadine Barnkothe,Bianca Teegen,Felix Luessi,Winfried Stöcker,Fred Lühder,Martin Begemann,Frauke Zipp,Klaus-Armin Nave,
Brain, Behavior, and Immunity (2023): 135-147
Current opinion in neurobiology (2023): 102782-102782
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biorxiv(2023)
NATUREno. 7964 (2023): 349-357
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