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His scientific work covers the entire translational pipeline, from the development of disease theories via the creation of computational methods to their application in clinical studies. A central goal is the development of clinically useful “computational assays” for psychiatry and psychosomatics. Based on generative models of brain activity and behaviour, the hope is that such assays will support more precise diagnostics and individualized treatment recommendations, leading to a transformation of clinical practice and redefinition of mental diseases. Current research foci include psychosis and brain-body interactions in fatigue and depression.
In order to enable the clinical validation of his work, Klaas founded the Translational Neuromodeling Unit (TNU) at Zurich, an interdisciplinary institution with the mission to translate advances in computational neuroscience into tools for clinical practice. The TNU assembles computational scientists and clinicians under one roof and operates a dedicated research clinic for evaluating the diagnostic and prognostic utility of computational assays in prospective patient studies.
His track record includes pathophysiological theories of schizophrenia, fatigue and depression, the development of open source and widely used computational tools (e.g. for investigating brain connectivity, Bayesian model selection) as well as numerous studies on psychiatric and psychosomatic disease mechanisms. His work has been recognized by various awards and honours, including the Wiley Young Investigator Award for Human Brain Mapping and election to the Max Planck Society.
In order to enable the clinical validation of his work, Klaas founded the Translational Neuromodeling Unit (TNU) at Zurich, an interdisciplinary institution with the mission to translate advances in computational neuroscience into tools for clinical practice. The TNU assembles computational scientists and clinicians under one roof and operates a dedicated research clinic for evaluating the diagnostic and prognostic utility of computational assays in prospective patient studies.
His track record includes pathophysiological theories of schizophrenia, fatigue and depression, the development of open source and widely used computational tools (e.g. for investigating brain connectivity, Bayesian model selection) as well as numerous studies on psychiatric and psychosomatic disease mechanisms. His work has been recognized by various awards and honours, including the Wiley Young Investigator Award for Human Brain Mapping and election to the Max Planck Society.
研究兴趣
论文共 386 篇作者统计合作学者相似作者
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Alexander J Hess,Sandra Iglesias, Laura Koechli,Stephanie Marino,Matthias Mueller-Schrader, Lionel Rigoux,Christoph Mathys,Olivia K Harrison,Jakob Heinzle, Stefan Fraessle,Klaas Enno Stephan
biorxiv(2024)
Neuroscience and biobehavioral reviews (2024): 105608-105608
Sharon Chi Tak Lee,Jorge Palacios,Derek Richards, Anna K. Hanlon,Kevin Lynch,Siobhan Harty,Nathalie Claus,Lorraine Swords,Veronica O'Keane,Klaas Enno Stephan,Claire M. Gillan
Biological Psychiatryno. 9 (2023): S54-S55
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Lilian Aline Weber,Peter Thestrup Waade, Nicolas Legrand, Anna Hedvig Møller,Klaas Enno Stephan,Christoph Mathys
CoRR (2023)
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BMC medical educationno. 1 (2023): 159-8
Biological Psychiatryno. 9 (2023): S129-S129
Matthias Müller-Schrader,Jakob Heinzle,Alfred Müller, Christian Lanz, Oliver Häussler, Martin Sutter, Andreas Eggspühler, Stefania Mare,Birte Toussaint,Inês Pereira,Frederike H Petzschner,Katja Wiech,
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