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Bio
I am Kiwon Lee working with Dr. Mortimer Poncz in the Division of Hematology at Children's Hospital of Philadelphia. In my Ph.D., I studied with Dr. Kwon in South Korea on the role of the large-scale chromatin architectures in gene regulation. To explore my knowledge of chromatin biology during hematopoiesis, I joined Dr. Gerd Blobel’s laboratory as a postdoctoral fellow at the Children’s Hospital of Philadelphia. I focused on studying dynamic enhancer looping structures and the functional relationship with transcription regulation in hematopoiesis. In this study, I discovered that an enhancer stably contacts a cognate promoter region but also dynamically contacts through its gene body as transcription elongation progresses. This conceptional model is provocative that can substantially contribute to the understanding of three-dimensional chromatin structures and transcription mechanisms at the c-Kit locus, one of the master transcription regulators, during hematopoiesis. Since I joined Dr. Mortimer Poncz's laboratory as a research associate, my research interest has shifted to translational applications in how the defects in key transcriptional regulators such as RUNX1 can affect lineage-specific differentiation and cancer development. It has been well known that heterozygous defects in RUNX1 are responsible for a familial platelet disorder with associated myeloid malignancy (FPDMM) and an increased risk of myelodysplasia and acute myeloblastic leukemia. However, since animal models do not recapitulate some of phenotypes of FPDMM, my colleagues and I focus on establishing a human CD34-derived ex-vivo megakaryopoiesis system in RUNX1 depletion and establishing a mouse-human hybrid model by xeno-transplantation into immunocompromized mice. These ex-vivo and in-vivo model systems could be useful preclinically for drug testing before committing to a clinical trial to correct phenotypes of FPDMM.
Research Interests
Papers共 7 篇Author StatisticsCo-AuthorSimilar Experts
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Fabiola Del Carpio-Cano,Guangfen Mao, Lawrence E. Goldfinger,Jeremy Wurtzel,Liying Guan, Mohammad Afaque Alam,Kiwon Lee, Mortimer Poncz,A. Koneti Rao
BLOOD ADVANCESno. 7 (2024): 1699-1714
Bloodno. 18 (2023): 2170-2172
Fabiola Del Carpio-Cano,Guangfen Mao,Lawrence E. Goldfinger,Jeremy Wurtzel, Liying Guan, Afaque Mohammad Alam,Kiwon Lee,Mortimer Poncz, Angara Koneti Rao
Blood (2023): 1218
Bloodno. 3 (2023): 260-270
Blood (2023): 2561
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