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Research Focus
The main emphasis of the research in the laboratory is on the fundamental principles that regulate signaling via G protein coupled receptors (GPCR). GPCRs mediate a vast variety of critical biological processes ranging from proliferation and motility to cellular reception and excitability. GPCR signaling pathways are of particular importance for the nervous system function where they control many fundamental processes including excitability, differentiation, sensory perception, and synaptic transmission. Importantly, but not surprisingly, even a subtle imbalance in GPCR signaling often leads to the most profound nervous system disorders ranging from blindness and cognitive problems to grave neurological diseases.
Specifically, our laboratory is interested in understanding the intricate regulatory dynamics of G protein pathways in the following two neuronal systems.
Basal ganglia where G proteins mediate reward behavior and movement coordination underlying not only addictive effects of abused drugs such as opioids and cocaine but also dysfunctions observed in movement disorders such as Parkinson's disease, Huntington’s disease, Tourette syndrome, and tardive dyskinesia.
Retina where G protein signaling systems of primary sensory neurons, photoreceptors, and downstream ON-bipolar cells act in tandem to generate responses to light and synaptically encode them to enable our vision. Dysfunctions in these processes are known to be the leading causes of a range of ocular pathologies including macular degeneration and congenital night blindness.
The main emphasis of the research in the laboratory is on the fundamental principles that regulate signaling via G protein coupled receptors (GPCR). GPCRs mediate a vast variety of critical biological processes ranging from proliferation and motility to cellular reception and excitability. GPCR signaling pathways are of particular importance for the nervous system function where they control many fundamental processes including excitability, differentiation, sensory perception, and synaptic transmission. Importantly, but not surprisingly, even a subtle imbalance in GPCR signaling often leads to the most profound nervous system disorders ranging from blindness and cognitive problems to grave neurological diseases.
Specifically, our laboratory is interested in understanding the intricate regulatory dynamics of G protein pathways in the following two neuronal systems.
Basal ganglia where G proteins mediate reward behavior and movement coordination underlying not only addictive effects of abused drugs such as opioids and cocaine but also dysfunctions observed in movement disorders such as Parkinson's disease, Huntington’s disease, Tourette syndrome, and tardive dyskinesia.
Retina where G protein signaling systems of primary sensory neurons, photoreceptors, and downstream ON-bipolar cells act in tandem to generate responses to light and synaptically encode them to enable our vision. Dysfunctions in these processes are known to be the leading causes of a range of ocular pathologies including macular degeneration and congenital night blindness.
研究兴趣
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Journal of Biological Chemistryno. 3 (2024)
Andreas Papapetropoulos,Stavros Topouzis,Steve P. H. Alexander,Miriam Cortese-Krott,Dave A. Kendall,Kirill A. Martemyanov,Claudio Mauro, Nithyanandan Nagercoil,Reynold A. Panettieri Jr,Hemal H. Patel, Rainer Schulz,Barbara Stefanska,
BRITISH JOURNAL OF PHARMACOLOGYno. 11 (2024): 1553-1575
Dominik Nelic,Nikolai Chetverikov,Martina Hochmalová, Christina Diaz,Vladimír Doležal,John Boulos,Jan Jakubík,Kirill Martemyanov, Alena Janoušková-Randáková
Journal of Neurologyno. 7 (2024): 1-5
Jana Domínguez-Carral,William Grant Ludlam, Mar Junyent Segarra,Montserrat Fornaguera Marti, Sol Balsells,Jordi Muchart,Dunja Čokolić Petrović,Iván Espinoza,Juan Dario Ortigoza-Escobar,Kirill A Martemyanov
Annals of neurology (2023)
BRITISH JOURNAL OF PHARMACOLOGY (2023): S1-S22
SCIENCE SIGNALINGno. 795 (2023): eadd9539-eadd9539
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