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The overall objective is to understand structure-function relationships of proteins, particularly snake venom toxins, and their mechanism. Snake venoms are rich sources of toxins that interfere with various physiological processes. We are specifically interested in protein families of phospholipase A2 (PLA2) enzymes, serine proteinases, three-finger toxins and helveprins. The functional diversity despite the structural similarity and the presence of functional sites in different segments of the toxins makes our research interesting and challenging. The functional sites are used in designing proteins with novel biological activities and prototypes of therapeutic agents.
The overall objective is to understand structure-function relationships of proteins, particularly snake venom toxins, and their mechanism. Snake venoms are rich sources of toxins that interfere with various physiological processes. We are specifically interested in protein families of phospholipase A2 (PLA2) enzymes, serine proteinases, three-finger toxins and helveprins. The functional diversity despite the structural similarity and the presence of functional sites in different segments of the toxins makes our research interesting and challenging. The functional sites are used in designing proteins with novel biological activities and prototypes of therapeutic agents.
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BMC Genomicsno. 1 (2024): 1-22
International Journal of Molecular Sciencesno. 22 (2023): 16389-16389
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Shih-Chia Yeh, Tania Strilets,Wei-Lian Tan,David Castillo, Hacene Medkour, Felix Rey-Cadilhac, Idalba M. Serrato-Pomar,Florian Rachenne,Avisha Chowdhury,Vanessa Chuo,Sasha R. Azar,Moirangthem Kiran Singh,
CHEMno. 8 (2023): 2237-2254
Scientific reportsno. 1 (2023): 1-12
Justin Kok Soon Tan, Elaine Shi An Chen,Yibing Dong,Hui Fang,Cho Yeow Koh,R. Manjunatha Kini,Sangho Kim,Hwa Liang Leo,Choon Hwai Yap
ADVANCED MATERIALS INTERFACESno. 10 (2023)
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