Current appointments Professor of Developmental Neuroscience, University of Edinburgh Director of the Simons Initiative for the Developing Brain Director of the Patrick Wild Centre, Associate Director of the Centre for Brain Development and Repair (India) Selected markers of esteem SFARI – Grant Review Panel Chair, Gordon Research Conference, Fragile X and Autism Seconded to the Wellcome Trust Neuroscience PhD Board External Advisory Board – Cardiff DEFINE CDKL5 Forum, Board member Building Brains Book; Intro to neural development (2nd Edition 2016) Selected publications 1.Booker S et al. Altered dendritic spine function and integration on a mouse model of Fragile X Syndrome. BioRxiv. September 2018. 2.Domanski APF et al . Cellular and synaptic phenotype compensations limit circuit disruption in Fmr1 – KO mouse layer 4 barrel cortex but fail to prevent deficits in information processing. BioRxiv September 2018. 3.Saxena K et al. Experimental contributions to social dominance in a rat model of Fragile X Syndrome. Proc Bio Sci June 2018. 4.Thomson S et al. Cell type-specific translation profiling reveals a novel strategy for treating fragile X syndrome. Neuron 2017 5.Crocker-Buque et al. Altered thalamocortical development in the SAP102 knockout model of intellectual disability. Hum Mol Genet. (2016) PMID: 27466188. (2016). 6.Barnes SA et al. Convergence of hippocampal pathophysiology in Syngap +/- and Fmr1 -/y mice, J Neurosci. 35; 15073-15081. (2015). 7.Till SM et al. Conserved hippocampal cellular pathophysiology but distinct behavioural deficits in a new rat model of FXS. Hum Mol Genetics. 2015. 8.Wijetunge L et al. Stimulated emission depletion (STED) microscopy reveals nanoscale defects in the developmental trajectory of dendritic spine morphogenesis in a mouse model of fragile X syndrome. J Neurosci 34:6405-6412 (2014) 9.Henderson C et al. Reversal of disease-related pathologies in the Fragile X mouse model by selective activation of GABA-B receptors with Arbaclofen. Sci Transl Med. 4; 152ra128. (2012). 10.McMahon AC, et al. Activity Dependant alternative promoter usage and alternative splicing enable SynGAP isoforms to exert opposing effects on synaptic strength. Nature comms. 3:900 (2012).