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Our lab investigates the impact of phages on the evolution and epidemiology of Vibrio cholerae, which is the causative agent of the severe diarrheal disease cholera. As a waterborne disease, cholera is a serious threat in areas of the world where sanitation is poor and access to safe drinking water is limited. Phages that specifically infect and kill V. cholerae are thought to modulate the inter-epidemic persistence of V. cholerae in the environment, thus impacting the occurrence and severity of outbreaks; however, uniquely, these phages also travel with V. cholerae into the human host and continue to prey on their bacterial host during infection. Therefore, phages have the unique potential to impact all aspects of the V. cholerae life cycle (including environmental persistence, infectivity and dissemination), on both a short and long-term evolutionary scale.
Our current focus is towards an understanding of the molecular basis for the anti-phage activity of a group of mobile genetic elements in epidemic V. cholerae. You can find more on our website!
Our current focus is towards an understanding of the molecular basis for the anti-phage activity of a group of mobile genetic elements in epidemic V. cholerae. You can find more on our website!
Research Interests
Papers共 54 篇Author StatisticsCo-AuthorSimilar Experts
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Caroline M Boyd,Kimberley D Seed
bioRxiv : the preprint server for biology (2024)
Kishen M. Patel,Kimberley D. Seed
bioRxiv the preprint server for biology (2023)
mBiono. 6 (2023)
Meer T. Alam,Carla Mavian,Taylor Paisie,Massimiliano S. Tagliamonte,Melanie N. Cash,Angus Angermeyer,Kimberley D. Seed,Andrew Camilli, Felicien Masanga Maisha, Raphael KABANGWA KAKONGO SENGA,Marco Salemi,J. Glenn Morris,
Emerging Infectious Diseasesno. 12 (2022): 2482-2490
Research Square (Research Square) (2022)
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