Her work focuses on issues related to the health impacts of climate change, including advocating for public health strategies to prepare for and prevent these impacts, and partnering with city and state governments to make health preparedness a more central feature of climate adaptation plans. She has researched heat- and ozone-related mortality and illnesses, possible connections between climate, pollen, allergies and asthma, and links between climate change and infectious diseases such as dengue fever. She was among the researchers who participated in the Intergovernmental Panel on Climate Change's 2007 Fourth Assessment Report. Dr. Knowlton's project group at NRDC recently launched an innovative website that allows people to zoom in on health effects of climate change in their own community. The web pages use cutting edge mapping technology to show people local risks of flooding, drought, heat, pollen, ozone smog, and mosquito-borne dengue fever. The site also informs people about what's needed to protect their families and reduce climate change.