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The goal of the Jones lab is to identify novel therapeutic targets for mental health disorders. Specifically, we focus on schizophrenia, depression and drug abuse. Dysfunctions in the physiology of GABAergic interneurons are implicated in all three disorders, and we use animal models to identify specific neurophysiological deficits that can be targeted for future drug development. Currently we are examining the role of fast-spiking interneurons in these disorders at several levels of organization, including characterizing biophysical properties of critical ion channels, all the way up to behavioral analyses in whole animals. We utilize a number of tools including transgenic mice and zebrafish, optogenetics, multi-electrode physiology in our work. The ultimate goal of the lab is to help find better treatments for schizophrenia, depression and drug abuse.
The goal of the Jones lab is to identify novel therapeutic targets for mental health disorders. Specifically, we focus on schizophrenia, depression and drug abuse. Dysfunctions in the physiology of GABAergic interneurons are implicated in all three disorders, and we use animal models to identify specific neurophysiological deficits that can be targeted for future drug development. Currently we are examining the role of fast-spiking interneurons in these disorders at several levels of organization, including characterizing biophysical properties of critical ion channels, all the way up to behavioral analyses in whole animals. We utilize a number of tools including transgenic mice and zebrafish, optogenetics, multi-electrode physiology in our work. The ultimate goal of the lab is to help find better treatments for schizophrenia, depression and drug abuse.
研究兴趣
论文共 10 篇作者统计合作学者相似作者
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eneurono. 7 (2023): ENEURO.0167-23.2023
Nandkishore Prakash,Heidi Y Matos,Sonia Sebaoui,Luke Tsai,Tuyen Tran, Adejimi Aromolaran, Isabella Atrachji, Nya Campbell,Meredith Goodrich,David Hernandez-Pineda,Maria Jesus Herrero,Tsutomu Hirata,
The Journal of comparative neurologyno. 2 (2023): e25545-e25545
Nandkishore Prakash,Heidi Y Matos,Sonia Sebaoui,Luke Tsai,Tuyen Tran, Adejimi Aromolaran, Isabella Atrachji, Nya Campbell,Meredith Goodrich,David Hernandez-Pineda,Maria Herrero,Tsutomu Hirata,
Journal of Comparative Neurology (2022)
Patricia M. Garay,Alex Chen, Takao Tsukahara, Jean Carlos Rodríguez Díaz,Rafi Kohen,J. Christian Althaus, Margarete A. Wallner,Roman J. Giger,Kevin S. Jones,Michael A. Sutton,Shigeki Iwase
PloS oneno. 10 (2014): e109303-e109303
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