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Bio
My research experience retains a strong modelling theme - spanning from developmental biology to cancer biology and now to computational biology. I completed my PhD at the MRC Human Genetics Unit, Edinburgh, supported by the University of Edinburgh. My work focussed on developmental models of embryonic melanocyte development and regeneration in the zebrafish model, with a view to uncovering novel pathways that are regulated in development but dysregulated in disease. My work here was centred around chemical-genetics techniques, drug screening and timelapse confocal imaging of the melanocytic lineage. From this work I became fascinated with how melanocyte lineage pathways are dysregulated in melanoma progression. I moved to the National Cancer Institute at the National Institutes of Health to develop my expertise in mouse models of melanoma metastasis and therapy resistance. My work here centred on mouse experimental metastases models, models of Immune Checkpoint Blockade (ICB) resistance, 'Omics analyses of melanoblast development and melanoma disease progression, fundamental molecular biology of Endoplasmic Reticulum (ER) stress biology, single-cell technologies and computational analysis.
From here, my work is coming full circle and I am excited to continue this trajectory in the multidisciplinary environment of the University of Manchester as a Wellcome Trust ISSF Fellow. I will continue to implement my developmental biology background to shed new light on embryonic lineage cell states that are re-acquired during melanoma metastasis. Particularly I will focus on mechanisms of regulation of a new Col6a1-expressing melanoblast subpopulation and an analogous Col6a1-expressing melanoma phenotype.
Research Interests
Papers共 19 篇Author StatisticsCo-AuthorSimilar Experts
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Vishaka Gopalan,Chun Wai Wong,Chi-Ping Day,Eva Perez-Guijarro,Maxwell P. Lee, Yuhong Jiang,Howard H. Yang, Maira Alves-Constantino,Antonella Sassano,Cari Smith,Mark Simpson,Sung Chin,
bioRxiv the preprint server for biology (2023)
Pharmacology & Therapeutics (2023): 108466-108466
Nature communicationsno. 1 (2023): 5983-21
Nature Computational Scienceno. 9 (2022): 577-583
bioRxiv (Cold Spring Harbor Laboratory) (2022)
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Author Statistics
#Papers: 19
#Citation: 262
H-Index: 5
G-Index: 16
Sociability: 5
Diversity: 0
Activity: 0
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