基本信息
views: 287
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
Bio
Kenneth Korach, Ph.D. leads the Receptor Biology Group. The group works to identify the estrogenic responses in target cells and to evaluate the different cellular mechanisms involved in their activation.
Environmental agents produce a variety of effects on the reproductive tract, some of which result in infertility and toxicity. In many cases such effects are direct and are produced by agents having estrogenic hormonal activity, but with little structural resemblance to the natural ligand. Mechanistically, hormonal activity is believed to be mediated through intracellular receptor proteins, although the tissues and specific responses vary, a primary response is alterations in gene transcription. The receptor demonstrates specific stereochemistry for endogenous compounds but appears to interact less selectively with exogenous chemicals.
Environmental agents produce a variety of effects on the reproductive tract, some of which result in infertility and toxicity. In many cases such effects are direct and are produced by agents having estrogenic hormonal activity, but with little structural resemblance to the natural ligand. Mechanistically, hormonal activity is believed to be mediated through intracellular receptor proteins, although the tissues and specific responses vary, a primary response is alterations in gene transcription. The receptor demonstrates specific stereochemistry for endogenous compounds but appears to interact less selectively with exogenous chemicals.
Research Interests
Papers共 619 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Endocrinologyno. 8 (2024)
Endocrinologyno. 3 (2024)
IUPHAR/BPS guide to pharmacology CITEno. 1 (2023)
April K Binder,Danielle L Peecher, Amanda J Qvigstad, Silvia D Gutierrez, Jennifer Magaña,David B Banks,Kenneth S Korach
British Journal of Pharmacologyno. S2 (2023): S223-S240
Journal of the Endocrine Societyno. Supplement_1 (2023)
Journal of the Endocrine Societyno. Supplement_1 (2022)
Load More
Author Statistics
#Papers: 594
#Citation: 55233
H-Index: 121
G-Index: 223
Sociability: 8
Diversity: 1
Activity: 1
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn