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Blood vessels are uniquely designed to detect low oxygen (hypoxia) and regulate blood flow accordingly. Hypoxia dilates systemic vessels (e.g., coronary arteries) to match oxygen delivery with metabolic demand and pulmonary arteries constrict to optimize gas exchange in the lung. My laboratory has identified a novel oxygen “sensing” mechanism using hydrogen sulfide (H2S). Known for centuries as a toxic and malodorous gas with the smell of rotten eggs, H2S has recently come to the fore as an endogenously produced signaling molecule in the cardiovascular, nervous, and gastrointestinal systems. My research involves three aspects of H2S biology; 1) the role of H2S in oxygen sensing in the cardiovascular system, 2) H2S production and metabolism in tissues, and 3) the applicability of a variety of newly developed H2S-donating drugs in physiology and medicine. These studies are especially relevant to coronary artery disease, stroke, COPD, sleep apnea and altitude acclimation.
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AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGYno. 4 (2023): H888-H891
Kenneth R Olson,Kasey J Clear,Yan Gao,Zhilin Ma, Nathaniel M Cieplik, Alyssa R Fiume,Dominic J Gaziano,Stephen M Kasko,Jennifer Luu, Ella Pfaff,Anthony Travlos,Cecilia Velander,
Kenneth R. Olson,Kasey J. Clear,Paul J. Derry,Yan Gao, Zhilin Ma, Nathaniel M. Cieplik, Alyssa Fiume,Dominic J. Gaziano,Stephen M. Kasko, Kathleen Narloch,Cecilia L. Velander, Ifeyinwa Nwebube,
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