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I am applying novel imaging techniques to investigate human bone diseases. Research in the bone group focuses on osteoporotic fragility fractures and osteoarthritis by examining bone structure and shape in health and disease. With scientists from the University Engineering for Clinical Practice initiative, we pioneered a way of assessing the 3D structure and shape of cortical bone structure in life called Cortical Bone Mapping (CBM). We have used CBM to discover not only that there are patches of focal osteoporosis in women with hip fracture, but also that various therapies and exercise interventions make the femur cortex thicker in key areas at risk of fracture. We are also interested in histological and high resolution CT analysis of bone, as well as osteocyte signals and their role in skeletal regulation.
I am applying novel imaging techniques to investigate human bone diseases. Research in the bone group focuses on osteoporotic fragility fractures and osteoarthritis by examining bone structure and shape in health and disease. With scientists from the University Engineering for Clinical Practice initiative, we pioneered a way of assessing the 3D structure and shape of cortical bone structure in life called Cortical Bone Mapping (CBM). We have used CBM to discover not only that there are patches of focal osteoporosis in women with hip fracture, but also that various therapies and exercise interventions make the femur cortex thicker in key areas at risk of fracture. We are also interested in histological and high resolution CT analysis of bone, as well as osteocyte signals and their role in skeletal regulation.
研究兴趣
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Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research (2023)
European Radiologyno. 11 (2023): 8333-8342
Tom D Turmezei,Samantha B Low, Simon Rupret,Graham M Treece,Andrew H Gee, James W MacKay,John A Lynch,Kenneth ES Poole,Neil A Segal
Osteoarthritis Imagingno. 2 (2022): 100069
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