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Currently within the CICBDD Lead Discovery and Characterization Team, we develop comprehensive early drug discovery programs using a variety of methods including protein expression and purification, biochemical and cell assays, and screening in partnership with numerous collaborators at UNC. We have the ability to conduct compound screening using a library of over 200,000 drug-like small molecules assembled within the center. Our expertise is also in hit validation and triage methods, including use of biophysical methods. Following successful hit discovery and validation, we work with collaborators and chemists within the center to produce structure-activity data and additional mode-of-action studies. Our ultimate goals are to: 1) produce high quality chemical probes for exploring biology of drug targets, and 2) discover drug candidate molecules for treatment of unmet medical needs.
The majority of our activities and interests are exploring targets within the epigenetic and chromatin modification network and prosecuting novel targets, including signal transduction proteins, enzymes and protein-protein interactions, for discovery of new potential cancer treatments.
Research Interests
Papers共 66 篇Author StatisticsCo-AuthorSimilar Experts
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Nature Communicationsno. 1 (2024): 1-10
The EMBO journalno. 14 (2024): 2835-2839
Eric M Merten,John D Sears,Tina M Leisner, Paul B Hardy, Anirban Ghoshal,Mohammad Anwar Hossain,Kesatebrhan Haile Asressu,Peter J Brown,Michael A Stashko,Laura Herring,Angie L Mordant, Thomas S Webb,
bioRxiv : the preprint server for biology (2024)
bioRxiv : the preprint server for biologyno. 2 (2024): e0293548-e0293548
Journal of the American Chemical Societyno. 28 (2023): 15065-15070
Alzheimer's & Dementiano. S7 (2023)
bioRxiv : the preprint server for biology (2023)
Journal of medicinal chemistryno. 20 (2023): 14133-14149
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Author Statistics
#Papers: 67
#Citation: 3433
H-Index: 22
G-Index: 47
Sociability: 6
Diversity: 3
Activity: 26
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