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The Margulies Lab examines mechanisms of myocardial remodeling to identify targets for therapeutic interventions. Many of our inquiries are initiated by multilevel examinations of explanted human heart tissues obtained at the time of transplantation or organ donation to permit insights into both the heterogeneity of myocardial adaptations to disease and identification of dominant mechanisms and responses. The Margulies lab has a longstanding focus on load-dependent myocardial remodeling with current studies focusing on mechanisms of load-dependent maturation, mechanical memory and pathological myocardial hypertrophy. In addition, the lab is actively engaged in studies examining regulation of contractility by microtubules and other cytoskeletal elements, cardiotoxicity associated with VEGF-anti-angiogenic tyrosine kinase inhibitors, disease-associated shifts in cardiac metabolism, mechanisms of inherited cardiomyopathies, advanced myocardial phenotyping using digital pathology and machine learning techniques, and integrated genomic inquiries designed to identify molecular mechanisms of myocardial pathology. Increasingly, complementary use of primary human cardiac myocytes, iPSC-derived cardiac myocytes and engineered cardiac microtissues are employed as versatile tools to balance human relevance and mechanistic clarity to advance these inquiries. Our work also includes, strategic patient-based proof-of-concept studies.
Research Interests
Papers共 638 篇Author StatisticsCo-AuthorSimilar Experts
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Qianru Wang, Tiffany M Tang, Michelle Youlton,Chad S Weldy, Ana M Kenney,Omer Ronen, J Weston Hughes, Elizabeth T Chin, Shirley C Sutton,Abhineet Agarwal, Xiao Li,Merle Behr,Karl Kumbier, Christine S Moravec, W H Wilson Tang,Kenneth B Margulies, Thomas P Cappola, Atul J Butte,Rima Arnaout,James B Brown,James R Priest,Victoria N Parikh,Bin Yu,Euan A Ashley
Nature cardiovascular research (2025)
Nadina R Latchman,Tyler L Stevens,Kenneth C Bedi,Benjamin L Prosser,Kenneth B Margulies,John W Elrod
bioRxiv the preprint server for biology (2025)
Henry Daniell,Geetanjali Wakade,Smruti K. Nair,Rahul Singh, Steven A. Emanuel, Barry Brock,Kenneth B. Margulies
PHARMACEUTICSno. 1 (2025)
Moydul Islam,David R Rawnsley,Xiucui Ma,Walter Navid,Chen Zhao, Xumin Guan,Layla Foroughi,John T Murphy, Honora Navid,Carla J Weinheimer,Attila Kovacs,Jessica Nigro, Aaradhya Diwan, Ryan P Chang,Minu Kumari,Martin E Young,Babak Razani,Kenneth B Margulies,Mahmoud Abdellatif,Simon Sedej,Ali Javaheri,Douglas F Covey,Kartik Mani,Abhinav Diwan
The Journal of clinical investigationno. 7 (2025)
Hali Hartman, Genevieve Uy,Keita Uchida,Emily A Scarborough, Yifan Yang, Eric Barr,Spencer Williams, Sanam L Kavar,Jeff Brandimarto, Li,Ling Lai,Joanna Griffin,Nora Yucel,Swapnil Shewale,Hari Rajagopal,Deborah M Eaton,Tanis Dorwart,Kenneth C Bedi,Crystal S Conn,Kenneth Margulies,Benjamin Prosser,Zoltan Arany,Jonathan J Edwards
bioRxiv the preprint server for biology (2025)
Konstanze Tan,Darwin Tay,Wilson Tan,Hong Kiat Ng,Eleanor Wong, Michael P. Morley,Gurpreet K. Singhera,Chang Jie Mick Lee, Pritesh R. Jain, Fei Li Tai, Paul J. Hanson,Thomas P. Cappola,Kenneth B. Margulies,Roger Foo,Marie Loh
Clinical Epigeneticsno. 1 (2025): 1-17
Hypertension Researchpp.1-14, (2025)
Julien Ochala, Miao Feng, Qian Wang, Chahida Chaami,Edgar Nollet, Christopher T A Lewis,Anthony L Hessel, Michelle Michels, Kenneth C Bedi,Kenneth B Margulies,Jose R Pinto, Kenneth S Campbell,Diederik W D Kuster,Jolanda van der Velden
Inez Duursma, Edgar E. Nollet, Valentijn J. Jansen, Janaya A. Malone, Jet S. Bloem,Kenneth Bedi,Kenneth B Margulies, Stephan Arend Cornelis Schoonvelde,Michelle Michels,Nicole N van der Wel,Jolanda van der Velden,Tyler J. Kirby,Diederik W.D. Kuster
biorxiv(2025)
Eric D Smith, Karen Jin, Brianna Ferguson, Yao-Chang Tsan, Samuel J DePalma, Joshua Meisner, Aaron Renberg,Kenneth Bedi, Sabrina Friedline,Kenneth B Margulies, Brendon M Baker,Adam S Helms
bioRxiv the preprint server for biology (2025)
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Author Statistics
#Papers: 668
#Citation: 23533
H-Index: 79
G-Index: 142
Sociability: 8
Diversity: 3
Activity: 176
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