基本信息
浏览量:39
职业迁徙
个人简介
Research Interests
Investigating the Role of Astrocyte Signaling in Brain Function
Research Synopsis
Approximately 50% of the mammalian brain is composed of astrocytes. These cells are present in every region of brain, are always closely associated with neuronal elements, and exhibit a wide variety of morphological phenotypes and neurotransmitter receptors. It is striking that while these cells constitute the largest single population of cells in brain, we know very little concerning their role in brain function. Many neurobiologists believe that astrocytes play a critical role in buffering extracellular potassium levels within the narrow range required for neuronal activity. Similarly, astrocytes are thought important in removing glutamate following its release at neuronal synapses.
A primary goal of our laboratory is to determine how astrocytes and neurons are signaling one another and the functional outcome of neuron astrocyte conversation. Our working hypothesis is that there are microdomains within astrocytic syncytium that interact with neuronal synapses to facilitate or to dampen neuronal excitability and/or neurotransmission. Through a combination of 2-photon imaging in live animals, electrophysiological, and behavioral studies using genetically-engineered mice we hope to begin unraveling the role of these cells in neurophysiology and disease.
Investigating the Role of Astrocyte Signaling in Brain Function
Research Synopsis
Approximately 50% of the mammalian brain is composed of astrocytes. These cells are present in every region of brain, are always closely associated with neuronal elements, and exhibit a wide variety of morphological phenotypes and neurotransmitter receptors. It is striking that while these cells constitute the largest single population of cells in brain, we know very little concerning their role in brain function. Many neurobiologists believe that astrocytes play a critical role in buffering extracellular potassium levels within the narrow range required for neuronal activity. Similarly, astrocytes are thought important in removing glutamate following its release at neuronal synapses.
A primary goal of our laboratory is to determine how astrocytes and neurons are signaling one another and the functional outcome of neuron astrocyte conversation. Our working hypothesis is that there are microdomains within astrocytic syncytium that interact with neuronal synapses to facilitate or to dampen neuronal excitability and/or neurotransmission. Through a combination of 2-photon imaging in live animals, electrophysiological, and behavioral studies using genetically-engineered mice we hope to begin unraveling the role of these cells in neurophysiology and disease.
研究兴趣
论文共 77 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Scientific reportsno. 1 (2020): 14181-14181
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn