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Bio
The focus of Dr. Walley’s research is to investigate 1) the mechanism of decreased left ventricular contractility and other organ failure during sepsis and 2) the impact of genotype on patient outcomes in sepsis and systemic inflammatory states. Dr. Walley translates basic discoveries into clinical practice in the ICU. Together with Drs. Russell and Boyd, he recently demonstrated that blocking the function of PCSK9, an enzyme that inhibits the clearance of endogenous cholesterol from blood, is associated with increased pathogen clearance via the LDL-receptor, a decreased inflammatory response, and improved septic shock outcome. This important discovery facilitated the emergence of anti-PCSK9 therapies as one of the most promising treatments for sepsis. This discovery has led to further investigation into the role of lipoproteins in sepsis. T
raining the next generation of clinician scientists is the other passion in my career. I led a multicentre CIHR Strategic Training in Health Research project over the course of 12 years. This led to over 50 postdoctoral trainees launching prominent academic and industry careers.
raining the next generation of clinician scientists is the other passion in my career. I led a multicentre CIHR Strategic Training in Health Research project over the course of 12 years. This led to over 50 postdoctoral trainees launching prominent academic and industry careers.
Research Interests
Papers共 409 篇Author StatisticsCo-AuthorSimilar Experts
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STEM CELLS TRANSLATIONAL MEDICINEno. 4 (2024): 346-361
Chel Hee Lee,Mohammad M. Banoei, Mariam Ansari,Matthew P. Cheng,Francois Lamontagne,Donald Griesdale, David E. Lasry,Koray Demir,Vinay Dhingra,Karen C. Tran,Terry Lee,Kevin Burns,
Critical Careno. 1 (2024): 1-16
Critical care explorationsno. 11 (2023): e0997-e0997
CMAJ openno. 4 (2023): E672-E683
Pratik Sinha,V Eric Kerchberger,Andrew Willmore, Julia Chambers,Hanjing Zhuo,Jason Abbott,Chayse Jones,Nancy Wickersham, Nelson Wu,Lucile Neyton,Charles R Langelier,Eran Mick,
The Lancet. Respiratory medicineno. 11 (2023): 965-974
Journal of proteome researchno. 1 (2023): 52-70
METABOLITESno. 11 (2023): 1142-1142
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2023)
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BMJ Open Respiratory Researchno. 1 (2023): e001810-e001810
Critical Careno. 1 (2023): 250-12
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