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My research concerns the sequence specific recognition of DNA by small molecules, oligonucleotides and proteins, and the formation of unusual DNA structures (triplexes and quadruplexes). Compounds that bind to DNA in a sequence specific fashion have potential for artificially controlling gene expression and may be used as anticancer or antiviral agents. Several DNA binding antibiotics are currently used in cancer chemotherapy, and we are seeking to understand the molecular mechanisms by which they bind to DNA with a view to designing new agents with improved selectivity. In all our studies we make extensive use of the footprinting technique, using both natural and synthetic DNA fragments, and have developed this assay as a powerful tool for measuring the specificity, stability and kinetics of ligand-DNA interactions. This has been used to determine the sequence selectivity of several DNA-binding small molecules.
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Clive S. Mason,Tim Avis,Chenlin Hu, Nabeetha Nagalingam,Manikhandan Mudaliar,Chris Coward,Khurshida Begum, Kathleen Gajewski,M. Jahangir Alam,Eugenie Basseres,Stephen Moss, Stefanie Reich,
Antimicrobial agents and chemotherapyno. 5 (2023): e0156322-e0156322
Cancer Researchno. 12_Supplement (2022): 1750-1750
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Clive Mason, Tim Avis,Chenlin Hu, Nabeetha Nagalingam,Manikhandan Mudaliar, Chris Coward,Khurshida Begum, Kathleen Gajewski,M Jahangir Alam,Stephen Moss, Stefanie Reich, Esther Duperchy,
Research Square (Research Square) (2022)
George Procopiou,Paul J. Jackson,Daniella M. di Mascio,Jennifer L. Auer, Paolo Andriollo, Ilona Pysz,Khondaker M. Rahman,Keith R. Fox,David E. Thurston
Cancer Researchno. 12_Supplement (2022): 1749-1749
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