基本信息
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职业迁徙
个人简介
Research areas
Late effects of cancer treatment and stem cell transplantation
Chronic graft-versus-host disease
Transplantation for sickle cell and autoimmune diseases
Knowledge engineering
Early on, Dr. Sullivan and the team at Fred Hutchinson Cancer Research Center developed a systematic investigative approach for the diagnosis and treatment of chronic graft-versus-host disease (GVHD), the major cause of late morbidity and non-relapse mortality following allogeneic stem cell transplantation (SCT). As a result of this work, it became clear that blood and marrow transplant recipients require systematic long-term follow-up to evaluate and treat late complications of high-dose chemoradiotherapy and SCT.
The program grew into a large multidisciplinary team, resulting in improvement in patient outcome and quality of life. Through the late events project, he also contributed to outcomes research, computer decision support systems, and knowledge engineering for follow-up care. With quality of life as a focus, research pursued the application of SCT to diseases with high morbidity but little immediate mortality. For young patients with advanced, symptomatic sickle cell disease, myeloablative conditioning and SCT from an HLA-identical sibling has led to an 86% long-term survival free of sickle cell disease. For individuals with autoimmune diseases such as multiple sclerosis, scleroderma, and systemic lupus erythematosus, current therapy is often incomplete and significant morbidity from the disease or its treatment is observed.
研究兴趣
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Transplantation and cellular therapyno. 7 (2023): 404-405
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Transplantation and cellular therapyno. 7 (2023): 403-403
FRONTIERS IN IMMUNOLOGYno. 10 (2023): 1809-11
Bólno. 2 (2023): 22-33
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Transplantation and cellular therapyno. 4 (2023): 217-221
Ankoor Shah,Jan Storek,Rob Woolson,Ashley Pinckney, Lynnette Keyes-Elstein,Paul K Wallace,Gregory D Sempowski,Peter McSweeney,Maureen D Mayes,Leslie Crofford, M E Csuka,Kristine Phillips,
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