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We aim to understand how early changes in the endothelium and vascular wall are related to the initiation and development of vascular diseases, with a particular focus on nitric oxide signalling.
Diabetes, high cholesterol, smoking and high blood pressure are all associated with abnormalities in the function of the endothelium, the single-cell lining of blood vessels. Of particular significance are abnormalities in the action of nitric oxide (NO), one of several important molecules produced in the endothelium that help to maintain the health of the blood vessel wall. These abnormalities accelerate the processes that lead to vascular disease, including inflammation, thrombosis and atherosclerotic plaque formation.
Production of NO, by nitric oxide synthase enzymes, is highly regulated and depends on the co-factor tetrahydrobiopterin, which is made within endothelial cells. Once NO is produced, it interacts with molecular targets in the cell, but is rapidly inactivated by reactive oxygen species (ROS). Nitric oxide synthases can produce ROS as well as NO, the balance between the two determining the biological actions and pathological importance of these pathways.
Diabetes, high cholesterol, smoking and high blood pressure are all associated with abnormalities in the function of the endothelium, the single-cell lining of blood vessels. Of particular significance are abnormalities in the action of nitric oxide (NO), one of several important molecules produced in the endothelium that help to maintain the health of the blood vessel wall. These abnormalities accelerate the processes that lead to vascular disease, including inflammation, thrombosis and atherosclerotic plaque formation.
Production of NO, by nitric oxide synthase enzymes, is highly regulated and depends on the co-factor tetrahydrobiopterin, which is made within endothelial cells. Once NO is produced, it interacts with molecular targets in the cell, but is rapidly inactivated by reactive oxygen species (ROS). Nitric oxide synthases can produce ROS as well as NO, the balance between the two determining the biological actions and pathological importance of these pathways.
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JACC: Cardiovascular Imagingno. 7 (2024): 835-837
Imaging (2024)
NATURE MEDICINEno. 5 (2024): 1-8
bioRxiv (Cold Spring Harbor Laboratory) (2024)
Liam Steven Couch, James W. Garrard, John A. Henry,Rafail A. Kotronias,Bashir Alaour, Giovanni Luigi De Maria,Keith M. Channon,Adrian P. Banning, Alexander Richard Lyon,Michael Marber,Thomas Edward Kaier
OPEN HEARTno. 1 (2024)
Samer Fawaz,Federico Marin,Sarosh A Khan,Rupert F G Simpson,Rafail A Kotronias, Jason Chai, Oxford Acute Myocardial Infarction (OxAMI) Study Investigators,Firas Al-Janabi,Rohan Jagathesan,Klio Konstantinou,Shah R Mohdnazri,Gerald J Clesham,
Roberto Scarsini,Rafail A Kotronias,Francesco Della Mora,Leonardo Portolan, Stefano Andreaggi,Stefano Benenati,Federico Marin, Sara Sgreva, Alberto Comuzzi,Caterina Butturini,Gabriele Pesarini,Domenico Tavella,
Henry W West,Muhammad Siddique,Michelle C Williams,Lucrezia Volpe, Ria Desai,Maria Lyasheva, Sheena Thomas,Katerina Dangas, Christos P Kotanidis,Pete Tomlins, Ciara Mahon,Attila Kardos,
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