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Receptor-type transmembrane proteins at the plasma membrane and their ligand-type secretory proteins play critical roles in intercellular communication. These proteins gain their own three-dimensional structure to exert their function with assistance from molecular chaperones and folding enzyme present in the endoplasmic reticulum (ER), the first organelle they encounter after synthesis on ribosomes. Under a variety of physiological and pathological conditions, however, this protein quality control system is compromised, resulting in the occurrence of ER stress characterized by the accumulation of unfolded proteins in the ER. Essentially all eukaryotic cells are equipped with a way to cope with this abnormal situation promptly and adequately, which is termed the unfolded protein response (UPR). This fact tells us the critical importance of protein folding in our cell and body. Dr. Mori has unraveled the mechanism of yeast and mammalian UPR and is analyzing physiological significance of the UPR and its involvement in development and progression of various diseases.
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Papers共 169 篇Author StatisticsCo-AuthorSimilar Experts
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Mariko Kikuchi, Miyo Yoshimoto,Tokiro Ishikawa, Yuto Kanda,Kazutoshi Mori,Toshiya Nishimura,Minoru Tanaka
DEVELOPMENTno. 5 (2024)
The Keio journal of medicineno. 1 (2024): 13-13
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Cell structure and functionno. 2 (2023): 123-133
Satoshi Ninagawa, Masaki Matsuo,Deng Ying, Shinya Aso,Kazutoshi Matsushita, Akane Fueki,Shunsuke Saito,Koshi Imami,Yasuhiko Kizuka,Tetsushi Sakuma,Takashi Yamamoto,Hirokazu Yagi,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Satoshi Ninagawa, Masaki Matsuo,Deng Ying, Shinya Aso,Kazutoshi Matsushita, Akane Fueki,Shunsuke Saito,Koshi Imami,Yasuhiko Kizuka,Tetsushi Sakuma,Takashi Yamamoto,Hirokazu Yagi,
crossref(2023)
LIFE SCIENCE ALLIANCEno. 8 (2023): e202201771-e202201771
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