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Bio
The bioinformatical branch of our group uses computational methods to discover new domain types or to detect new instances of known domains in poorly characterized proteins. The analysis of a domain's conservation pattern or its phyletic distribution often allows a precise prediction of its function, which is amenable to experimental validation. By combining information on multiple domains in a protein - and by integrating other data sources obtained from a wide variety of model organisms - it is possible to make useful predictions on the function and properties of novel proteins, even if they have never been studied experimentally.
The experimental branch of our group will generate some of the data sources necessary for a successful protein functional prediction, one example being a domain-domain interaction map of major model organisms. In addition, we will complement the bioinformatical screens for protein functions by suitable experimental screens and validate some of the bioinformatical findings. The feasibility of this approach has been documented in several case studies that can be looked up in our publication list.
Research Interests
Papers共 296 篇Author StatisticsCo-AuthorSimilar Experts
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Walter W. Chen,Tony A. Rodrigues,Daniel Wendscheck,Ana G. Pedrosa,Chendong Yang,Tânia Francisco, Till Möcklinghoff, Alexandros Zografakis, Bernardo Nunes-Silva, Reut Ester Avraham, Ana R. Silva,Maria J. Ferreira,
biorxiv(2024)
Matteo Veronese,Sebastian Kallabis, Alexander Tobias Kaczmarek, Anushka Das,Lennart Robers, Simon Schumacher, Alessia Lofrano,Susanne Brodesser, Stefan Müller,Kay Hofmann,Marcus Krüger,Elena I Rugarli
Life Science Allianceno. 8 (2024)
crossref(2024)
Matteo Veronese,Sebastian Kallabis, Alexander Tobias Kaczmarek, Anushka Das,Lennart Robers, Simon Schumacher, Alessia Lofrano,Susanne Brodesser, Stefan Müller,Kay Hofmann,Marcus Krüger,Elena I Rugarli
Life science allianceno. 8 (2024)
Matteo Veronese,Sebastian Kallabis, Alexander Tobias Kaczmarek, Anushka Das,Lennart Robers, Simon Schumacher, Alessia Lofrano,Susanne Brodesser,Stefan Müller,Kay Hofmann,Marcus Krüger,Elena I. Rugarli
Life Science Allianceno. 2 (2023)
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