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My research interest present time is to study the molecular mechanisms of cancer metastasis. Metastasis is the major cause of cancer-related death. Although several studies to understand the initiation and progression of primary tumors have been performed, metastasis remains an understudied field. It is therefore important to study metastasis in mechanistic detail and to discover novel pathways that have therapeutic implications.
I am now co-leading the GU Oncology Focus Group of Buffet Cancer Center and work closely with the GU Oncology clinicians. Our research here has been focused on angiogenic growth factors and their role in promoting prostate cancer progression and metastasis. We are particularly working on vascular endothelial growth factor-C (VEGF-C) and its receptor, neuropilin-2 (NRP-2), in prostate cancer and recently observed a novel role of this axis in endocytic trafficking. We observed that enhanced endocytosis in prostate cancer cells due to the activation of the VEGF-C/NRP2 axis promotes cancer-promoting functions such as autophagy and activation of growth factor receptors by facilitating their rapid recycling to the plasma membrane. A comprehensive understanding of this novel function of NRP2 would be therefore crucial to develop an effective therapy against this aggressive, incurable stage of prostate cancer.
I am now co-leading the GU Oncology Focus Group of Buffet Cancer Center and work closely with the GU Oncology clinicians. Our research here has been focused on angiogenic growth factors and their role in promoting prostate cancer progression and metastasis. We are particularly working on vascular endothelial growth factor-C (VEGF-C) and its receptor, neuropilin-2 (NRP-2), in prostate cancer and recently observed a novel role of this axis in endocytic trafficking. We observed that enhanced endocytosis in prostate cancer cells due to the activation of the VEGF-C/NRP2 axis promotes cancer-promoting functions such as autophagy and activation of growth factor receptors by facilitating their rapid recycling to the plasma membrane. A comprehensive understanding of this novel function of NRP2 would be therefore crucial to develop an effective therapy against this aggressive, incurable stage of prostate cancer.
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Juhi Mishra,Sanika Bodas,Sreyashi Bhattacharya, Dipanwita Das, Sheeraz UnNazir,Samikshan Dutta,Kaustubh Datta
Cancer Researchno. 6_Supplement (2024): 1493-1493
Cancer Researchno. 6_Supplement (2024): 3589-3589
Aaqib M. Bhat,Bhopal C. Mohapatra,Haitao Luan,Insha Mushtaq,Sukanya Chakraborty, Siddhartha Kumar, Wangbin Wu, Ben Nolan,Samikshan Dutta,Matthew D. Storck, Micah Schott,Jane L. Meza,
Scientific Reportsno. 1 (2024): 13523-13523
PROSTATEno. 3 (2024): 277-284
Advances in Cancer Research (2024)
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Samikshan Dutta,Sreyashi Bhattacharya, Hanna Harris,Ridwan Islam,Sanika Bodas,Navatha Polavaram,Juhi Mishra, Dipanwita Das,Parthasarathy Seshacharyulu, Achyuth Kalluchi, Anirban Pal,Manish Kohli,
Research square (2023)
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