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个人简介
The Lilley Group focuses on the development and application of technologies which enable the measurement of the dynamic proteome in space and time in cells in a high-throughput manner. More specifically, we are interested in looking at the changes in abundance, location, interacting partners, post-translational modification status and structure of proteins during dynamic cellular processes such as differentiation. We also develop methods to determine the subcellular distribution of the transcriptome and how this changes upon perturbation, and the complement of proteins that form dynamic ribonuclear complexes. Finally, we aim to determine the spatial and temporal links between the trafficking of the proteome and its corresponding transcriptome.
Our technologies involve innovative experimental pipelines coupled with quantitative mass spectrometry, RNA-seq, and computational tools. We use these methods to dissect cellular mechanisms related to stress, drug treatment, differentiation and disease in many collaborative projects with academic labs and the pharmaceutical industry.
Our technologies involve innovative experimental pipelines coupled with quantitative mass spectrometry, RNA-seq, and computational tools. We use these methods to dissect cellular mechanisms related to stress, drug treatment, differentiation and disease in many collaborative projects with academic labs and the pharmaceutical industry.
研究兴趣
论文共 386 篇作者统计合作学者相似作者
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Dipan Roy,Poonam Mehra,Vaishnavi Mukkawar,Lisa Clark, Kevin Bellande,Joop EM Vermeer, Raquel Martin Arevallilo,Teva Vernoux, Kawinnat Sue ob,Andrew Jones,Ulrike Bechtold,Phil Mullineaux,
biorxiv(2024)
Natureno. 7993 (2024): 189-194
Nature Methodsno. 1 (2024): 60-71
NATUREno. 7993 (2024)
Nature communicationsno. 1 (2023): 4401-16
Journal of the American Society for Mass Spectrometryno. 7 (2023): 1330-1341
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