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She then joined the lab of Barbara Panning at UCSF for her postdoctoral studies, which got her excited about the X-inactivation problem. She uncovered that polycomb proteins and H3K27me3 accumulate on the inactive X chromosome in an Xist RNA-dependent manner. As result, H3K27me3 has become synonymous with X-inactivation and is the most widely used marker of the inactive X in and outside the field. This finding has supported the model that long-noncoding RNAs can, directly or indirectly, recruit chromatin-modifying complexes to their target sites. She then moved back to Boston to finish her postdoctoral training in the laboratory of Rudolf Jaenisch at the Whitehead Institute at MIT. There, she was exposed to various new topics from mouse development, neurodevelopmental diseases, cancer biology, DNA methylation problems etc. In the Jaenisch lab, Kathrin identified Polycomb proteins as general regulators of developmental genes in mammalian cells and provided insight into the role of this repressive chromatin complex in the maintenance of pluripotency, by defining the genome-wide targets of the PRC2 Polycomb complex and its downstream mark H3K27me3 in embryonic stem cells (ESCs) though the then new ChIP-chip method. Kathrin joined the faculty at the University of California Los Angeles in 2006. She serves on the editorial board of Cell, Science, Cell Stem Cell and other journals, and has held various leadership positions in the International Society for Stem Cell Research. She has also been selected as a HHMI Faculty Scholar. Outside of the lab, Kathrin enjoys spending time with friends and family and being active, playing tennis and baseball, hiking, biking, and skiing. Despite living in the US for a long time she still is rooting for the German national soccer team at the world cup.
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