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个人简介
Research Interests
alternative splicing; cyclic amp-dependent protein kinases; dystonic disorders; ion transport atpase; isoenzymes; ouabain; phosphoproteins; sodium; sodium-potassium-exchanging atpase
Research Narrative
Ion transport ATPases are enzymes with many critical functions in the body. The Membrane Biology Lab does research on the fundamental structure and biology of two ATPases and their specific regulators.
Mutations in one of the ATPases, a sodium pump, causes dystonia in patients, and the lab is developing a mouse model of the disease for research on treatments
The sodium pump is also critical for making cerebrospinal fluid, and the lab investigates its role in hydrocephalus, using both mice and the methods of biochemistry and molecular biology. The goal is to control hydrocephalus without surgical shunts
Another enzyme is a plasma membrane calcium pump, and the lab investigates the structural basis of its regulation by calmodulin
Mice with defects in ATPase regulators called FXYD proteins were discovered to have problems with either kidney function or insulin production, opening the door to new approaches to hypertension or diabetes research
研究兴趣
论文共 171 篇作者统计合作学者相似作者
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AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGYno. 3 (2024): H623-H635
Kyoko Hoshino,Kathleen J. Sweadner,Toshitaka Kawarai,Jonas Alex Saute, Joel Freitas,Joana Damasio,Karina C. Donis,Kazue Kimura, Hideki Fukuda,Masaharu Hayashi,Tetsuya Higuchi,Yoshio Ikeda,
The Journal of biological chemistry (2020): 100019-100019
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