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职业迁徙
个人简介
Our goal is to query molecular mechanisms and translate them into therapeutics for rare neurological disorders as well as neglected infectious diseases.
We study epigenetic regulation in neurodegenerative disorders, intellectual disability and chronic pain. We utilize computational big-data approaches and ‘systems’ validation in biochemical, cellular and preclinical murine models to move targeted brain-permeant therapy down the drug discovery and development pipeline.
Our work in neglected infectious diseases is in parasitic and bacterial pathogens and their engagement of the host response to define mechanisms of virulence and inflammatory disease and pathogenic drug targets.
Here a major focus is in malaria parasites, and their mechanisms of drug resistance, since resistance to antimalarials threatens global malaria control and elimination. To accelerate development of new therapies, we partner with pharmaceutical companies in innovative models of private public product-development partnerships.
研究兴趣
论文共 96 篇作者统计合作学者相似作者
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medrxiv(2024)
PLOS PATHOGENSno. 11 (2023): e1011776-e1011776
Laura Arribas-Carreira,Cristina Dallabona,Michael A Swanson,Joseph Farris,Elsebet Østergaard,Konstantinos Tsiakas,Maja Hempel, Cecile Aquaviva-Bourdain, Stefanos Koutsoukos,Nicholas V Stence,Martina Magistrati,Elaine B Spector,
bioRxiv : the preprint server for biology (2023)
Kasturi Haldar, Mohammed Shafiul Alam,Cristian Koepfli,Neil F. Lobo, Ching Shwe Phru, Muhammad Nazmul Islam,Abul Faiz,Wasif Ali Khan,Rashidul Haque
TRENDS IN PARASITOLOGYno. 9 (2023): 760-773
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