He was the first to report on survival benefits of a beta-blocker (1979), an ACE-inhibitor (1987), an angiotensinreceptor blocker (2003) and recently an ARNI (angiotensin receptor antagonist and neprilysin inhibitor 2014) in chronic heart failure. He has published widely in international journals with more than 600 publications in peer-reviewed journals, 340 original research papers and > 65000 citations.
He was Chairman of the Task Force on the Diagnosis and Treatment of Chronic Heart Failure that updated the ESC Guidelines 2005. He has participated in Steering Committees in numerous outcome trials in myocardial infarction and heart failure.