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We study fundamental problems in infection biology using a combination of molecular as well
as genome-wide and systems biology approaches. We are particularly interested in a better
understanding of the dynamic gene regulation during host-pathogen interplay, with a focus
on fungal pathogens such as Candida spp. On the pathogen side, we use reverse genetics,
systems biology and functional genomics strategies (gene deletions, RNA-Seq / Chip-Seq) to
(i) identify virulence and antifungal drug resistance genes, (ii) decipher the role of histone
modifications and chromatin alterations in morphogenetic switching or cell fate determination,
and (iii) study signaling mechanisms during fungal morphogenesis and host colonization. On
the host side, we exploit transcriptomics and proteomics of primary phagocytes
(macrophages, dendritic cells, neutrophils) and T cells to study (i) the mechanisms of gene
regulation underlying fungal immunity, (ii) the interplay of adaptive (T cells) and innate
(dendritic cells) immunity in fungal surveillance, and (iii) type I interferon signaling (i.e. IFNbeta) and inflammation controlling the function and activity of inflammatory phagocytes
(monocytes, neutrophils and T cells), and, (iv), the critical role of Th17 inflammation on
pathogen elimination in invasive fungal diseases
Research Interests
Papers共 250 篇Author StatisticsCo-AuthorSimilar Experts
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Trinh Phan-Canh,Philipp Penninger,Saskia Seiser,Narakorn Khunweeraphong,Doris Moser, Tamires Bitencourt,Hossein Arzani, Weiqiang Chen, Lisa-Maria Zenz, Andrej Knarr, Diana Cerbu,Sabrina Jenull,
biorxiv(2024)
Birgit Strobl, Sara Miranda,Caroline Lassnig, Kristina Schmidhofer, Hrönn Kjartansdottir,Claus Vogl,Simone Tangermann,Irina Tsymala,Mathias Müller,Karl Kuchler
crossref(2024)
crossref(2024)
Raju Shivarathri,Manju Chauhan,Abhishek Datta, Diprasom Das, Adela Karuli,Sabrina Jenull,Karl Kuchler,Shankar Thangamani,Anuradha Chowdhary,Jigar V. Desai,Neeraj Chauhan
bioRxiv the preprint server for biology (2024)
PLoS Pathogensno. 11 (2023): e1011677-e1011677
Microbes and infection (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
PLOS PATHOGENSno. 11 (2023)
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Author Statistics
#Papers: 247
#Citation: 12168
H-Index: 61
G-Index: 106
Sociability: 6
Diversity: 3
Activity: 32
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